☠️ Dangerous ☠️
These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Lithium
There is a large number of reports indicating a high seizure and psychosis risk from this combination.

🛑 Unsafe 🛑
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol
Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

⚠️ Caution ⚠️
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

Amphetamines
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

Cannabis
Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.

Cocaine
Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

↗ Low Risk & Synergy ↗
These drugs work together to cause an effect greater than the sum of its parts, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before combining drugs.

2C-T-X

2C-X

5-MEO-XXT

AMT

Dextromethorphan

DOX

Ketamine

LSD

MAOIS

MDMA

Mescaline

Mushrooms

MXE

NBOMES

Nitrous

PCP

➡ Low Risk & No Synergy ➡
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.

Caffeine

Opioids

↘ Low Risk & Decrease ↘
Effects are subtractive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.

Alcohol

Benzodiazepines

GHB/GBL

SSRIS