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Alcohol

Basic Information

Summary

Alcohol is a CNS depressant that acts through the GABAreceptor, and is one of the most common strong psychoactives used by humans. It has a long history of use and its intoxicating effects are well-studied and documented. It remains legal in most parts of the world.

Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Common

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Oral
Light1-2units
Common2-4units
Heavy5-6units

NOTE: Alcohol consumption should be spread out over a few hours and ideally separated by water breaks. Check the label on alcohol for unit content

Duration

All ROAs
Onset15-30 minutes
Duration1.5-3 hours
After-effects6-48 hours

Detection

12 hrs blood, 6-12 hrs saliva, 6-24 hrs urine

Effects

relaxation, mood lift, happiness, sociability, lowered inhibitions, analgesia, slurred speech, flushed skin, drowsiness, tolerance, euphoria, amnesia

Aliases

etoh
beer
ethanol
booze
hooch

See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • Ketamine
    • Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
  • MXE
    • There is a high risk of memory loss, vomiting and severe ataxia from this combination.
  • DXM
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.
  • GHB/GBL
    • Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.
  • Opioids
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
  • Tramadol
    • Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
  • Benzodiazepines
    • Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.

Unsafe

  • PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  • Cocaine
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.
  • MAOIs
    • Tyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.

Caution

  • αMT
    • aMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
  • N2O
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
  • Amphetamines
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
  • MDMA
    • Both MDMA and alcohol cause dehydration. Approach this combination with caution, moderation and sufficient hydration. More than a small amount of alcohol will dull the euphoria of MDMA
  • SSRIs
    • Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

Low risk & Increased Effects

  • Cannabis
    • In excess, this combination can cause nausea.

Low risk & Decreased Effects

  • Mushrooms
  • LSD
  • DMT
  • Mescaline
  • DOx
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  • NBOMes
  • 2C-x
  • 2C-T-x
    • Both these classes of compound can interact unpredictably. Caution should be exercised.
  • 5-MeO-xxT

Low risk & No Synergy

References & Notes

General