A very popular CNS stimulant available on prescription and black markets. Recreational in high doses, producing mild euphoria and an abundance of energy. Popular in eastern europe and the US.
Stimulants excite the nervous system and increase physiological function.Read more on TripSit Wiki...
These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.Read more on TripSit Wiki...
Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.
NOTE: Depending on purity, amphetamine dosage *will* vary
|Effects||Increased focus, abundance of energy, racing thoughts, elevated heartrate.|
|Detection||Blood: 12 hours. Saliva: ~3 days. Urine: 1-4 days. Hair: Up to 90 days.|
|Marquis||Strong reddish orange - Dark reddish brown|
|Avoid||other stimulants, and depressants. Mixing depressiants and stimulants is very rough on the heart. MXE is also to be avoided (possibility of serotonin syndrome)|
- The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
- Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
- Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
- The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
- Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
- This combination can easily lead to hypermanic states
- The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
- No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
- Risk of tachycardia, hypertension, and manic states
- This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
- This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
- Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
- Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
- Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Low risk & Decreased Effects
- Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction
Low risk & No Synergy
References & Notes
- Treatment for amphetamine dependence and abuse. - http://www.ncbi.nlm.nih.gov/pubmed/11687171
- Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic models - https://www.ncbi.nlm.nih.gov/pubmed/16143730
- Treatment for amphetamine dependence and abuse. - https://www.ncbi.nlm.nih.gov/pubmed/11687171
- Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model ps... - https://www.ncbi.nlm.nih.gov/pubmed/16143730
- The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, a... - https://www.ncbi.nlm.nih.gov/pubmed/18342307
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the w... - https://www.ncbi.nlm.nih.gov/pubmed/22289608
- Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psyc... - https://www.ncbi.nlm.nih.gov/pubmed/3527341
- L-DOPA exacerbates amphetamine-induced dopamine depletion. - https://www.ncbi.nlm.nih.gov/pubmed/9565967
- Amphetamines in the treatment of Parkinson's disease. - http://www.ncbi.nlm.nih.gov/pubmed/1097600
- Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine. - http://www.ncbi.nlm.nih.gov/pubmed/11343690
- Behavioral and neuropharmacological analysis of amphetamine and 2,5-dimethoxy-4-methylamphetamine in rats. - http://www.ncbi.nlm.nih.gov/pubmed/1208759
- Identification of di(beta-phenylisopropyl)amine as the main ingredient in illicit amphetamine tablets. - http://www.ncbi.nlm.nih.gov/pubmed/12645186
- Long-term opiate effects on amphetamine-induced dopamine release in the nucleus accumbens core and conditioned place preference. - http://www.ncbi.nlm.nih.gov/pubmed/14751461
- Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. - http://www.ncbi.nlm.nih.gov/pubmed/15337264
- Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonists. - http://www.ncbi.nlm.nih.gov/pubmed/15833596
- Christmas gingerbread (Lebkuchen) and Christmas cheer--review of the potential role of mood elevating amphetamine-like compounds formed in vivo and... - http://www.ncbi.nlm.nih.gov/pubmed/16007907
- Dual intoxication with diazepam and amphetamine: this drug interaction probably potentiates myocardial ischemia. - http://www.ncbi.nlm.nih.gov/pubmed/17320309
- Update on amphetamine neurotoxicity and its relevance to the treatment of ADHD. - http://www.ncbi.nlm.nih.gov/pubmed/17606768
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats. - http://www.ncbi.nlm.nih.gov/pubmed/21615721
- Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. - http://www.ncbi.nlm.nih.gov/pubmed/24296074
- Long-lasting effects of escalating doses of d-amphetamine on brain monoamines, amphetamine-induced stereotyped behavior and spontaneous nocturnal l... - http://www.ncbi.nlm.nih.gov/pubmed/2440058
- Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons. - http://www.ncbi.nlm.nih.gov/pubmed/25033183
- Acute methoxetamine and amphetamine poisoning with fatal outcome: a case report. - http://www.ncbi.nlm.nih.gov/pubmed/25060403
- [Antitussive effect of amphetamine]. - http://www.ncbi.nlm.nih.gov/pubmed/552131
- Amphetamine-clonidine interaction on neurotransmission in the vas deferens of the rat. - http://www.ncbi.nlm.nih.gov/pubmed/6098834
- Self-injection of amphetamine directly into the brain. - http://www.ncbi.nlm.nih.gov/pubmed/6415748
- Amphetamine-induced analgesia does not involve brain opioids. - http://www.ncbi.nlm.nih.gov/pubmed/6468501
- Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2'-methyl-MPTP. - http://www.ncbi.nlm.nih.gov/pubmed/7931228
- L-DOPA exacerbates amphetamine-induced dopamine depletion. - http://www.ncbi.nlm.nih.gov/pubmed/9565967
- Long-lasting psychotomimetic consequences of repeated low-dose amphetamine exposure in rhesus monkeys. - http://www.ncbi.nlm.nih.gov/pubmed/9885781
- Use of naltrexone has been found to successfully aid in recovery from amphetamine addiction - http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2008.08020304
- According to drugs.com 's interaction checker, there is a potential for serotonin syndrome when mixing amphetamines and ssri's. The threshold dose for danger however is unknown. https://www.drugs.com/interactions-check.php?drug_list=2543-0,679-0
- Amphetamine has a half life of 7-31 hours: Mosby's Dental Drug Reference Ninth Edition 2010
- Pregnancy category C according to the FDA. Evidence has shown usage during pregnancy can cause premature birth, low birthweight, and withdrawal syndrome in the baby. This occurs more often in abuse of adderall. Recommendation is to consult with a physician if you are pregnant.
- Pregnancy category C according to the FDA. - https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/011522s040lbl.pdf