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Bupropion

Basic Information

Summary

A frequently prescribed atypical antidepressant. Occasionally prescribed as an aid to smoking cessation. May lower seizure threshold in predisposed individuals. Poorly understood mechanism of action, probably an NDRI. Avoid combination with other drugs.

Stimulant

Stimulants excite the nervous system and increase physiological function.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Duration
Parent
Onset15-90 minutes
Duration11-21 hours
After-effects1-6 hours
Metabolites
Onset15-90 minutes
Duration20-37 hours
After-effects1-6 hours
Effects

    Effects lovingly provided by PsychonautWiki

    General-effectsMild - moderate increase in motor activity and agitation/excitement
    Adverse-effectsAgitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor, dizziness, excessive sweating, blurred vision, tachycardia, confusion, rash, hostility, cardiac arrhythmia, and auditory disturbance
    Overdose-symptomsSeizure, hallucinations, loss of consciousness, sinus tachycardia, ECG changes, bradycardia, cardiac failure, cardiac arrest, and death
    WarningBupropion lowers the seizure threshold and can induce seizures when excessive doses are used and/or when combined with CNS stimulants or other drugs that also lower the threshold, such as theophylline, steroids, some tricyclic antidepressants, and alcohol
    ChemistryIUPAC: (±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one | Formula: C13H18ClNO | Molecular Mass: 239.74 g/mol
    PharmacologyNDRI (Norepinephrine-Dopamine Reuptake Inhibitor); NDRA (Norepinephrine-Dopamine Releasing Agent); α3β2, α3β4, α4β2, and α7 nACh receptor antagonist
    PharmacokineticsProtein Binding: 84% (bupropion), 77% [hydroxybupropion (active metabolite)], 42% [threohydrobupropion (active metabolite)] | Metabolism: hepatic, primarily CYP2B6-mediated hydroxylation; both bupropion and hydroxybupropion (active metabolite) are CYP2D6 inhibitors | Excretion: renal (87%; 0.5% unchanged) and faecal (10%)
    LegalAustralia: Prescription Only (S4) | Canada: ℞-only | United Kingdom: POM | United States: ℞-only
    Aliaseswellbutrin
    zyban
    amfebutamone
    ContradictionsSeizure disorder, current or prior diagnosis of bulimia or anorexia nervosa, abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and anti-epileptic drugs, and MAOIs,
    See TripSit Wiki for more information about drug interactions

    Interactions

    Dangerous

    Unsafe

    Caution

    Low risk & Increased Effects

    Low risk & Decreased Effects

    Low risk & No Synergy

    References & Notes

    General