Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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1,4-Butanedioldepressant habit forming1,4-BD is a clear liquid with intoxicating Effects. It is a pro-drug for GHB, and has similar though reportedly inferior Effects. It also carries the potential for more health risks than GHB, such as liver toxicity.
2-methyl-2-butanolhabit formingdepressant tentativeA tertiary Alcohol that has sedative, hypnotic, and anxiolytic Effects. It is also roughly 20x more potent than Ethanol by weight.
3-OH-PHENAZEPAMtentativeresearch chemicalbenzohabit formingdepressant The 3-OH analogue of Phenazepam, which cuts the half life down quite a bit. Psychoactive Effects are mostly lead by its metabolites, rather than the drug itself.
6-MDDMopioidhabit formingtentativedepressant A semisynthetic Hydromorphone derivative with little recorded history of human use. Potentially 80x the potency of Morphine. Structurally related to desomorphine.
Acetylfentanylopioidresearch chemicalhabit formingdepressant Acetyl-Fentanyl is an opioid analgesic substance that is an analogue of Fentanyl. It's potency is roughly ~6.67 times that of Morphine. Making it ~15 times less potent than its parent compound Fentanyl.
Acrylfentanylopioidresearch chemicalhabit formingtentativedepressant A rare opioid and Fentanyl analogue (not to be confused with acetyl-Fentanyl), this drug is a powerful and potent analgesic. Little reliable information exists, even for basic usage such as dosage. Exercise extreme caution. Overdose may result in respiratory depression. Do not mix with depressants or stimulants. Potentially neurotoxic and carcinogenic.
Adinazolamdepressant habit formingtentativeBenzodiazepine derivative that has some antidepressant properties. Never FDA approved, yet however has been sold as a research chemical.
Afloqualonedepressant habit formingtentativeA rare analogue of Methaqualone, a sedative, intoxicating drug. Similar Effects to benzodiazepines, barbiturates and Alcohol. Never widely used due to photosensitivity and skin irritation issues, though it has seem some popularity in Japan.
AH-7921opioidresearch chemicalhabit formingdepressant Opioid analgesic that is selective for the μ-opioid receptor. It has around 80% the potency of Morphine when taken orally.
Alcoholdepressant habit formingcommonAlcohol is a CNS depressant that acts through the GABAreceptor, and is one of the most common strong psychoactives used by humans. It has a long history of use and its intoxicating Effects are well-studied and documented. It remains legal in most parts of the world.
Allobarbitalbarbituratetentativedepressant habit formingIs a barbiturate that was first made in 1912. It was primilary used as an anticonvulsant. Yet it has pretty much been outclassed by a newer generation of safer ones. Still in use in Poland.
Alprazolambenzohabit formingdepressant commonAn extremely common benzodiazepine better known as Xanax, frequently prescribed for the treatment of anxiety and panic disorders. Alprazolam is short-lasting and primarily anxiolytic, though also possesses hypnotic properties. At high doses amnesia and loss of inhibition are common. Do not mix with other depressants.
Amfecloralstimulantdepressant Is a stimulant drug of the phenethylamine">Phenethylamine and Amphetamine class. It was used as an appetite suppressant, yet is no longer marketed. It's also interesting that it acts as a prodrug to both Amphetamine and Chloral Hydrate.
Amobarbitaldepressant habit formingbarbiturateA sedative and hypnotic barbiturate first discovered in 1923. Formerly widely used recreationally and medically, barbiturates have declined in popularity with the appearance of benzodiazepines and other drugs with less serious consequences in overdose.
Ashwagandhadepressant supplementcommonIs an Adaptogen. It is commonly used for its ability to prevent anxiety. It also is helpful in relieving insomnia. It's name means "Smell of Horse" due to its smell and the traditional belief that ingesting the this herb will give you the strength and virility of a horse.
Baclofendepressant habit formingAlso known as Lioresal, Baclofen is a GABAb receptor agonist and central nervous system depressant used to treat spasticity, and holds promise as a treatment for alcoholism. It exhibits mild intoxicating Effects similar to Phenibut or Pregabalin.
Barbitalbarbituratehabit formingdepressant The first commercially available barbiturate. Was used commonly as a sleeping aid until the 1950s.
Bentazepambenzodepressant habit formingThienodiazepine that is an effective anxiolyric. Liver damage among other nasty things have been reported.
Bromadolopioiddepressant habit formingtentativeA very potent opioid that has an arylcyclohexylamine structure. Intial studies estimated that it was ~10,000x Morphine in animal studies. However that value has since decreased to ~504 times the potency of Morphine for the trans-isomer.
Bromantanedepressant stimulantresearch chemicalnootropicAn unusual stimulant and anxiolytic drug with dopamine and serotonin reuptake inhibition properties. Infamously used as a doping agent in the 1996 Olympics. There are some concerns it may exacerbate the underlying causes of Alzheimer's disease.
Bromazepambenzohabit formingdepressant A benzodiazepine drug with a medium-long duration, developed by Roche in the 1960s. Has primarily anxiolytic properties. May cause lowered inhibitions and amnesia in high doses.
Brotizolamdepressant benzohabit formingdepressant Benzodiazepine analogue which is sedating, hypnotic and anxiolytic. It is available as prescription medicine in much of Europe, and is an extremely potent drug active at only 80ug. May cause amnesia and lowered inhibitions in overdose. Danger of respiratory depression when combined with other depressants. Short half life.
Buprenorphineopioidhabit formingdepressant A semi-synthetic opioid analgesic also known as subutex. Often administered as Butrans patches, or in combination with Naloxone as Suboxone, a Heroin replacement therapy drug. Will cause withdrawals if you have an opioid tolerance and DON't wait long enough (typically around 48 hours) before taking this.
Butyrfentanylopioidresearch chemicalhabit formingtentativedepressant Potent short-acting opioid and Fentanyl analogue. Often dispensed in a nasal spray. This is an highly potent drug - exercise extreme caution. May cause respiratory depression and death in overdose.
Camazepambenzohabit formingtentativedepressant A benzodiazepine drug that is stronger in terms of anxiety relief than it is in terms of how hypnotic it is. It is a metabolite of Diazepam and has limited anticonvulsant properties.
Cannabisdepressant stimulantpsychedelichabit formingcommonA common and widely used psychoactive plant, which is beginning to enjoy legal status for medical and even recreational use in some parts of the world. Usually smoked or eaten, primary Effects are relaxation and an affinity towards food - a state described as being 'stoned.'
Carisoprodoldepressant habit formingA skeletal muscle relaxant drug also known as Soma, Carisoprodol has limited recreational value, however its main metabolite meprobamate has some moderate tranquilising properties. Sometimes found in concoctions with Codeine or Caffeine.
Chloral betainedepressant habit formingSedative-hypnotic drug that was introduced into the United States in the 60's. Betaine complex with Chloral hydrate, thus makes it act as an extended version of Chloral hydrate then to Trichloroethanol, which is responsible for most of its Effects.
Chloroformdepressant habit formingtentativeA naturally occurring organic compound once used as an anaesthetic. Has practically disappeared in this usage due to numerous harmful Effects including danger of sudden death through cardiac arrhythmia. Has been implicated in numerous murders. Highly unsafe.
Cinolazepamdepressant habit formingA benzodiazepine derivative drug with anxiolytic Effects but mainly hypnotic Effects. It is extremely effective for sleep aid but has mild euphoria compared to other benzos
Clobazambenzohabit formingdepressant A long acting half life benzo that focues on Anxiolytic and/or Anticonvulsant.
Clomethiazoledepressant research chemicalhabit formingtentativeStructurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce Effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute Alcohol withdrawal.
Clonazepambenzohabit formingdepressant commonA medium-length common prescription benzodiazepine, often used to treat panic attacks because of its relatively fast sublingual onset. Primarily anxiolytic, but also possessing of other benzo traits.
Clonazolambenzoresearch chemicalhabit formingdepressant commonA long lasting benzodiazepine with heavily hypnotic Effects. The safety profile is not well established, and there have been reports that people taking it three days in a row have had a seizure. Most comparable to Triazolam, but with a much longer half-life.
Clonidinedepressant commonIs a medication that is used to treat high blood pressure, anxiety, withdrawal (Typically from Alcohol, Opioids, Smoking) and many other uses.
Cloniprazepambenzodepressant habit formingtentativeProdrug for Clonazepam.
Clonitazeneopioidhabit formingdepressant research chemicalAn opioid that is roughly three times as potent as Morphine. Is related to Etonitazene, which is about 1000-1500x the potency of Morphine.
Clorazepatedepressant benzohabit formingdepressant Is a prodrug for Desmethyldiazepam which is responsible for most of the therapeutic Effects. Has a long half life, with the addition of Desmethyldiazepam as the main metabolite, which makes it much longer.
Clotiazepambenzohabit formingtentativedepressant Is a thienodiazepine substance. It differs from most other benzodiazepines in which the benzene ring has been replaced by a thiophene ring.
Cloxazolamdepressant habit formingBenzodiazepine derivate that is metabolised into Delorazepam. Which is where most of its Effects come from.
Codeineopioidhabit formingdepressant commonCodeine is a weaker opioid used to treat mild to moderate pain and to relieve cough. In many countries it is available over the counter in combination with paracetamol, which can easily be extracted to retrieve near-pure Codeine. For this reason, it is used widely as a recreational opioid. It is metabolised into Morphine in the body at a rate of 5% mg for mg.
Cyclizinedepressant First generation antihistamine and anticholinergic drug used to combat nausea and vomiting. Causes drowsiness. Like most antihistamines in high doses it induces delirium and vivid realistic hallucinations. Probably uncomfortable and not enjoyable.
Cyclobenzaprinedepressant habit formingcommonMuscle relaxant and CNS depressant used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Sometimes prescribed off-label for treatment of fibromyalgia or as a sleep aid. Has little recreational value alone, but may potentiate some opioids. May cause drowsiness, dry mouth and dizziness.
Daturadepressant tentativedeliriantA family of plants containing various Tropane alkaloids. Produces long-lasting deliriant Effects including very realistic and often unpleasant hallucinations along with short-term amnesia. Datura plants are toxic to humans, and potency varies greatly from plant-to-plant, making the drug extremely difficult to dose safely. Not typically regarded as recreational.
Delorazepambenzohabit formingdepressant Also known as chlordesmethyldiazepam, this uncommon benzodiazepine compound is primarily used for treatment of anxiety and Alcohol withdrawal, due to its long half-life (60-140 hours). It is also the active metabolite of Diclazepam and Cloxazolam.
Pethidineopioidhabit formingdepressant A phenylpiperidine opioid first synthesised by Otto Eisleb in 1939, better known by the names meperidine and pethidine. An analgesic, once widely prescribed it has since declined in usage due to the discovery of a toxic metabolite - norpethidine. Also reacts dangerously with many drugs.
Deschloroetizolambenzoresearch chemicalhabit formingtentativedepressant A Thienodiazepine which is close to its parent compound, Etizolam, whilst being significantly weaker and longer lasting.
Desmethylflunitrazepamdepressant benzohabit formingresearch chemicalBenzodiazepine that is a metabolite of Flunitrazepam, and has been sold as a research chemical.
Dextropropoxypheneopioiddepressant habit formingAn opioid analgesic that is an optical isomer of levopropoxyphene. Used to treat mild pain and often used for its antitussive properties. It has been taken off the market in Europe and US due to concerns of health issues relating to the Kidney, Liver, Heart and Respiratory Disorders. Just a bit stronger than Tramadol.
Diazepambenzohabit formingdepressant commonA very common and widely prescribed benzodiazepine with hypnotic and sedative qualities. The metre by which other benzodiazepines are compared. May cause amnesia and lowered inhibitions in excess. Has a relatively long half-life in comparison with other benzodiazepines.
Diclazepambenzohabit formingdepressant A benzodiazepine drug and analogue of Diazepam first synthesised by Leo Sternbach at Hoffman-LaRoche in 1960, it has become prominent as an RC benzodiazepine on the grey market in recent years, particularly with the decline in Etizolam availability. A sedative and hypnotic it is of intermediate to long half life with similar Effects to Diazepam, though 10x more potent.
Diethyl etherdepressant habit formingtentativeAn industrial solvent which is sometimes used recreationally as a dissociative anaesthetic, with a short length of action. Effects are similar to Alcohol. Leaves one's breath tasting and smelling strongly of ether for much longer than the experience lasts.
Dihydrocodeineopioidhabit formingdepressant A weak semi-synthetic opioid analgesic and antitussive (anti-cough) drug. Often sold as a syrup in combination with Aspirin or paracetamol. Not to be confused with the slightly less potent Codeine.
Dipipanoneopioiddepressant habit formingdepressant A powerful opioid of equivalent strength to Morphine, rarely seen outside of medical environments. Often used to treat severe pain where Morphine is contraindicated. Usually found in combination with the antihistamine Cyclizine, which potentiates it.
Doxylaminedepressant deliriantA first generation antihistamine and anticholinergic, originally used to treat nausea and itching, and later as a sleep aid. Causes drowsiness, and delirium in overdose. Sometimes used with opioids to combat nausea and potentiate Effects.
DPHdepressant deliriantcommonAn antihistamine which, when taken in smaller doses relieves allergies and insomnia. In larger doses works as a deliriant and can actually keep the user awake. Generally the 'high' of this drug is reported as dysphoric, potentially causing hallucinations indistinguishable from reality.
Dimenhydrinatedepressant deliriantcommonA combination of diphenhydramine and a mild stimulant to counteract the drowsiness accompanied by typical medical use of diphenhydramine. Roughly half the potency of DPH. Small doses can relieve motion sickness, reduce body load from opioids or DXM. Becomes a deliriant in high doses, keeping the user awake and often causing dysphoric, realistic hallucinations.
Estazolambenzohabit formingdepressant A rarely prescribed medium-duration prescription benzodiazepine. Mainly used as a hypnotic, it can cause amnesia and lowered inhibitions in excess.
Eszopiclonedepressant habit formingThe d-isomer of Zopiclone, this drug is a potent hypnotic 'Z' drug often used to treat insomnia. High doses may cause amnesia, delirium and lowered inhibitions. Should not be combined with any depressants. Limited recreational value.
Ethaqualonedepressant benzoresearch chemicalhabit formingdepressant Analogue of Methaqualone that was mostly marketed in France. Slightly weaker and shorter acting than the prior.
Ethylmorphineopioidhabit formingtentativedepressant A medium-strength opioid analgesic and analogue of Morphine. Considered less potent than Morphine but more potent than Codeine, and has been used in Germany for this reason. Said to have a 'ceiling' effect where no more euphoria occurs with increased dosage. Under investigation as a maintainance drug in opioid dependence therapy.
Etizolambenzoresearch chemicalhabit formingdepressant commonA thienodiazepine anxiolytic. Similar in action to benzodiazepine drugs. Relieves anxiety, causes sedation and mild euphoria. High doses can lead to losing memory of what happened while on the drug. Users often compulsively re-dose frequently leading to accidental blackouts. Can be found in pressed pharmaceutical pills from various countries, clandestine pill presses, or as a powder
Fentanylopioidhabit formingdepressant Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than Morphine, and is commonly used as a patch.
Flubromazepambenzoresearch chemicalhabit formingdepressant A somewhat common benzodiazepine drug. Sedative, hypnotic and anxiolytic, this compound is an analogue of Phenazepam. First discovered in the 1960s it was never marketed as a licit drug, but has recently become available as an RC. Not to be confused with Flubromazolam.
Flubromazolambenzoresearch chemicalhabit formingdepressant A very potent benzodiazepine derivative that is related to Triazolam and Pyrazolam. Popular in the research chemical scene, it is a potent sedative, hypnotic and anxiolytic. Potential for amnesia and reduced inhibitions in higher dose. Not to be confused with Flubromazepam, which is much less potent.
Flunitrazepambenzohabit formingdepressant Known as Rohypnol or 'roofies,' this infamous drug has similar qualities to most other benzodiazepines; sedating with strong hypnotic Effects. Despite being known as a 'date rape drug' has only been implicated in a small number of such crimes. Danger of respiratory depression in combination with other depressants. May cause amnesia and lowered inhibitions in overdose.
Flunitrazolambenzodepressant habit formingtentativeA very potent hypnotic Benzodiazepine. Triazolo version of Flunitrazepam.
Fluorophenibuttentativedepressant habit formingAn anxiolytic analogue of GABA and Phenibut, with similar activity to the latter. Expected to be 5-10 times as potent as Phenibut, some preliminary reports suggest tolerance builds more slowly.
Flurazepambenzohabit formingdepressant Benzodiazepine with an extremely long half life, between 40 and 250 hours. Mainly used for general anxiety disorder. Sedating, hypnotic, anxiolytic. Potential for amnesia and reduced inhibitions in overdose.
Flutazolambenzohabit formingdepressant A benzodiazepine derivative. It was invented in Japan, and has mainly stayed in that area. Similar potency to Diazepam, yet produces a more marked sedation and impaired coordination. Usually used as a treatment for Insomnia. A hypnotic and sedative which may cause amnesia and lowered inhibitions in high doses.
Flutoprazepambenzohabit formingdepressant A potent benzodiazepine that is roughly 4-5x the potency of Diazepam and has a longer duration, rarely seen outside of Japan. Sedative, hypnotic and anxiolytic. May cause amnesia and loss of inhibitions in excess. Do not mix with other depressants.
Furanylfentanylresearch chemicalhabit formingtentativeopioiddepressant An extremely potent opioid analgesic and analogue of fentanyl. Concrete information is difficult to obtain about even basic properties like active dose, though it is believed to be slightly less potent and shorter in duration than Butyrfentanyl. Exercise extreme caution. Will cause respiratory depression in overdose.
GABAdepressant supplementGamma-Aminobutyric Acid. Supplement used in calming some down. Does not pass the brain blood barrier.
Gabapentindepressant habit formingdepressant An analogue of GABA also known as Neurontin, originally developed to treat epilepsy. Commonly prescribed for neuropathic pain, it also has pronounced anxiolytic Effects leading to its use in treating anxiety disorders.
GBLdepressant habit formingcommonA pro-drug to GHB whose rapid absorption leads it to have a faster onset and shorter duration. Used in a similar manner to GHB, as a less-toxic alternative to Alcohol.
GHBdepressant habit formingcommonA euphoric depressant which is prescribed as a sleep aid and sometimes to help with Alcohol detox. Also used as a recreational depressant, as a non-toxic alternative to Alcohol, or to enhance sex.
Glaucineopioidhabit formingdepressant tentativeAn alkaloid that is found in several different scpecies in the Papaveraceae family. It has antiinflammatory and antitussive Effects. Can also be referred to as Yellow Horned Poppy.
Glutethimidedepressant habit formingIs a hypnotic sedative that was introduced in 1954, as a "safe" alternative to barbiturates to treat insomnia. Anecdotally long term use has had Effects similar to withdrawal, while still on a stable dose of the drug.
Halazepambenzohabit formingdepressant A less common prescription benzodiazepine and derivative of Nordazepam. Also known as Paxipam, it is no longer prescribed in the USA. Sedating, hypnotic and anxiolytic. High doses may induce amnesia and lowered inhibitions.
Halothanedepressant tentativeA powerful inhalant anaesthetic generally used in a medical setting to induce unconsciousness, as a supplement with Ketamine or Fentanyl.
Heroinopioidhabit formingdepressant commonA powerful opioid drug derived from Morphine, with two to four times the potency. Also known as diacetylmorphine. Infamous for its high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 while trying to find a less addictive alternative to Morphine. One of the most popular drugs of all time.
Hexobarbitalbarbituratedepressant habit formingtentativeIs a barbiturate that was once used for inducing anesthesia for surgery. It has a very rapid onset, and a short duration of Effects.
Hydrocodonedepressant opioidhabit formingdepressant commonA Codeine-derived opioid generally unheard of outside the United States. Generally mild in Effects, used as an analgesic and cough-supressant. Sometimes used recreationally.
Hydromorphoneopioidhabit formingdepressant An opioid that is roughly 5x the potency of IV Morphine. Only comes in IR tablets in the US, and is given mostly as XR in other countries. It is frequently used in hospitals for short, but immediate pain relief during procedures requiring the patient to be awake. Also frequently used as a recreational opiate.
Hydroxyzinedepressant deliriantAn antihistamine drug commonly prescribed for anxiety, itchiness, nausea, and insomnia. Hydroxyzine has also been used to potentiate the analgesia of opioids as well as diminishing the negative Effects of opioids, such as itchiness.
Ibogainepsychedelicopioiddissociativedepressant An alkaloid found in many African plants most famously Iboga, with psychedelic and hallucinogenic properties. May be unpleasant. Traditionally used in tribal environments for coming-of-age rituals, it has recently been used as an alternative treatment for drug addiction although this usage has not been backed by conclusive data in humans. Has killed in overdose.
Isomethadoneopioidhabit formingtentativedepressant Once a pharmaceutical drug also known as isoamidone, this opioid analgesic and Methadone analogue was withdrawn from the market and is seldom seen today. Rarely abused, though reports state it is around twice as potent as Methadone, and more euphoric.
Kannahabit formingdepressant A South African plant containing numerous psychoactive alkaloids, including mesembrine and mesembrenone. The first written account of the substance was in 1662. The pharmacology of these compounds is poorly understood, but they are suspected to be serotonin uptake inhibitors and potentially monoamine releasers. Said to suppress appetite, produce mild euphoria and reduce anxiety.
Kavadepressant habit formingTropical evergreen shrub with large heart-shaped leaves and woody stems. Its thick roots are mashed or ground and made into a cold and bitter-tasting beverage used similarly to Alcohol. It has a long history of ritual and recreational use in Pacific Polynesia and is now a common herbal product, used widely by those in certain societies as part of a 'Kava Culture.'
Ketazolamdepressant habit formingBenzodiazepine derivative that has most of the common benzodiazepine Effects. Has been seen to have similar effectiveness when compared to Diazepam, with milder side-Effects. Is marketed in few countries.
Ketobemidoneopioidhabit formingdepressant An opioid analgesic drug that also acts as an NDMA antagonist. Found to be as potent as Morphine in physical side Effects, and has high potential for addiction like all opioids do. Overdose may lead to respiratory depression/death. Do not mix with CNS depressants or stimulants. Caution should be used for asthmatic users.
Kratomopioidstimulanthabit formingdepressant commonA drug made out of the leaves of Mitragyna Speciosa, which is related to coffee. Stimulating at lower doses, with opioid Effects at higher doses. Frequent heavy use can cause physical addiction and withdrawals.
Libriumbenzohabit formingdepressant Chlordiazepoxide, a medium-acting benzodiazepine drug prescribed mostly for sleep purposes. Sedative and hypnotic, it may cause lowered inhibitions and amnesia in high doses.
Loprazolamdepressant habit formingIs an Imidazolobenzidazepine derivative that has all the classic benzodiazepine Effects. Is usually only prescribed for a short amount of time for insomnia.
Lorazepambenzohabit formingdepressant commonAn intermediate acting benzodiazepine commonly known as Ativan, commonly prescribed as an alternative to Xanax. Sedating, hypnotic and anxiolytic. Potential to induce amnesia and lowered inhibitions in overdose. Do not combine with other depressants.
Lormetazepambenzodepressant habit formingRelatively rare prescription benzodiazepine. Short acting with a short half life. Generally only seen in the Netherlands. Sedative, hypnotic and anxiolytic.
Marinoldepressant tentativeSynthetically created Δ9-THC, the main psychoactive ingredient in Cannabis.
Mebroqualonedepressant research chemicalhabit formingtentativeA short acting analogue of Methaqualone, that is much more potent.
Meclonazepambenzohabit formingdepressant tentativeA benzodiazepine related to Clonazepam discovered by Hoffman-LaRoche in the 1960s. Potentially useful in treating schistosomiasis. Has been sold on the grey market as a recreational drug but has not seen widespread popularity.
Medazepamdepressant benzohabit formingBenzodiazepine derivative that has all of the classic benzodiazepine Effects. Is a long-acting benzodiazepine drug (Half life of 36-200 hours) Is rarely prescribed in most countries. Is also a prodrug for Diazepam. Think of it as Desoxy-Diazepam if you'd like to.
Metaxalonedepressant Muscle relaxant, that is used to relieve pain from general pain, and other musculoskeletal conditions.
Methadoneopioidhabit formingdepressant commonA synthetic opioid drug used as an analgesic and is often used in detoxification off of other opioids. As it has a much longer half-life.
Methaqualonedepressant habit formingA pharmaceutical depressant and sedative phased out due to the better safety profile of benzodiazepines, part of the Qualone group of substances. Now very rare, except in South Africa.
Methylmethaqualonedepressant research chemicalhabit formingA more potent analogue of Methaqualone with a short duration. Thought to be potentially neurotoxic. Has pro-convulsive Effects.
Metizolambenzoresearch chemicaldepressant habit formingtentativeAlso known as desmethyletizolam, a thienodiazepine similar in Effects and structure to Etizolam, but around half as potent and with around a 60% longer half-life. A sedative, and hypnotic, it may cause amnesia and lowered inhibitions in excess.
Midazolambenzohabit formingdepressant A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines.
Morphineopioiddepressant habit formingdepressant commonThe prototypical opioid drug, a powerful analgesic with euphoric qualities, found in the seeds and wax of the plant papaver somniferum (Opium poppy). First isolated by Friedrich Sertürner in 1805, named for its sleep-inducing qualities. Do not combine with other depressants, may cause dangerous respiratory depression in overdose.
MT-45opioidresearch chemicalhabit formingdepressant A synthetic opioid drug with approximately 80% of the potency of Morphine, created by Dainippon Pharmaceutical in the 1970s. It has been used as a lead compound for the design of many related drugs. It has been associated with hearing loss. Structurally unrelated to most other opioid drugs.
Nifoxipambenzoresearch chemicalhabit formingtentativedepressant An uncommon and relatively new RC benzodiazepine, and metabolite of the hypnotic benzodiazepine Flunitrazepam. Little information about the pharmacological properties of this drug exists. Likely to be a strong sedative and hypnotic.
Nimetazepambenzohabit formingdepressant A pharmaceutical benzodiazepine with hypnotic and sedative Effects. Rarely seen in the West but reportedly very frequently abused in Malaysia.
Nitemazepambenzodepressant habit formingtentativeA new RC benzodiazepine based off the chemical structure of Nimetazepam. It is relatively new and not many experience reports exist on it. It is expected to feel similar to Temazepam.
Nitrazepambenzohabit formingdepressant Hypnotic Benzodiazepine, that is used for short term relief of anxiety and insomnia. It has a pronouced affect on respritory action.
Nitrazolambenzohabit formingdepressant tentativeHypnotic benzodiazepine that is the triazolo analogue of Nitrazepam and about 4x more potent compared to the parent compound. Also the dechlorinated derivative of Clonazolam with roughly 1/10 potency.
Chloral hydratedepressant habit formingChloral Hydrate, a sedative drug discovered in 1832 with a history of recreational use going back to the 19th century. Sometimes prescribed for extreme insomnia. For such an old drug, relatively little is known about its long-term term Effects on the body. Produces intoxication comparable to Alcohol or benzodiazepines.
Norflurazepambenzodepressant tentativehabit formingBenzodiazepine analogue that is an active metabolite to many other benzodiazepines, such as Flurazepam, Flutoprazepam, and Midazolam.
O-Desmethyltramadolopioidresearch chemicalhabit formingtentativedepressant A opioid analgesic which is the main active metabolite of Tramadol. Alone, it is a few times more potent than Tramadol and has additional affinity for δ and κ-opioid receptors. Has proven popular when sold, but these occasions have been rare due to patent rights.
Opiumopioidhabit formingdepressant commonOpium is a naturally occurring analgesic harvested as a latex from ripe Papaver somniferum (Opium poppy) pods. The sap of the poppy plant primarily contains Codeine and Morphine with the amounts varying by plant, which can be made into a tea and consumed raw, or further processed.
Oxazepambenzodepressant habit formingA prescription benzodiazepine with intermediate duration and half life. A sedative and hypnotic which may cause lowered inhibitions and amnesia in higher doses.
Oxazolamdepressant habit formingA benzodiazepine derivative that is a prodrug for desmethyldiazepam.
Oxycodoneopioidhabit formingdepressant commonA semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Sometimes known as 'hillbilly Heroin,' somewhat paradoxically since it is rather expensive. Reported as being a little more 'stimulating' than other opioids.
Oxymorphoneopioidhabit formingdepressant A powerful semisynthetic opioid analgesic also known as opana. A derivative of Morphine it is approximately ten times as potent. Has a low oral bioavailability, and as such it is usually insufflated or taken rectally.
Pagoclonedepressant habit formingtentativeresearch chemicalAn anxiolytic drug related to Zopiclone with no sedative or hypnotic qualities. Has been investigated as a possible Alcohol replacement. Related in structure and effect to Zopiclone and Zolpidem.
Dextromoramideopioidhabit formingdepressant Dextromoramide, a rare and powerful opioid analgesic approximately three times as potent as Morphine with a shorter duration. Generally only seen in the Netherlands. Reported as having strange and rapid tolerance behaviour.
4-Fluorobutyrfentanylopioidresearch chemicalhabit formingdepressant Rare, little known and extremely potent RC analogue of Fentanyl. This powerful opioid is generally only dispensed as a nasal spray. Handle with extreme caution and never mix with other depressants.
Parafluorofentanylopioiddepressant habit formingtentativeRare, little known and extremely potent analogue of Fentanyl developed by Janssen Pharmaceutica in the 1960s. Use with extreme caution and never mix with other depressants.
Pentazocinehabit formingdepressant opioidA synthetic opioid used as an analgesic. It is only used IM and IV in the medical field and has respiratory depressant Effects. It is pregnancy category C and schedule IV in the US.
Pentobarbitaldepressant habit formingbarbiturateA CNS depressant drug that is of the barbituate class. Typically not used often as it is easier to OD on than benzodiazepines, the new alternative to barbituates. Used often for insomnia, to cause sedation.
Phenazepambenzoresearch chemicalhabit formingdepressant A very long acting, potent and subtle benzodiazepine. Infamous for the calamitous experiences it tends to produce in people dosing unknown amounts. Prescribed in certain countries for epilepsy and Alcohol withdrawal.
Phenibutdepressant research chemicalhabit formingnootropicA derivative of GABA with the addition of a phenyl ring which allows it to cross the Blood Brain Barrier. Is mostly used as an anti-anxiety and anti-insomnia medication. Tolerance and physical dependency builds very quickly.
Phenobarbitaldepressant habit formingbarbiturateCNS depressant that is used mostly for insomnia (In older patients) and epliepsy (in younger patients) And it a very strong narcotic, that can be taken most ways. It's used less as "safer" alternatives have been made (Benzodiazepines).
Picamilonnootropicdepressant habit formingAn analogue of GABA that does pass the brain blood barrier, which is then hydrolyzed into GABA and Niacin. In which the GABA could produce an anxiolytic effect. The Niacin as a vasodilator. And is usually used as part of a nootropic stack.
Pinazepambenzodepressant habit formingBenzodiazepine that is solely an anxiolytic drug that lacks the hypnotic and motor impairment that most benzodiazepines do. The main metabolite of this is Nordazepam and to a lesser effect Oxazepam, which is where it gets most of its Effects
Ethchlorvynoldepressant habit formingSedative Hypnotic medication made in the 50's. It was used for short term help for insomnia (No longer than two weeks)
Prazepambenzodepressant habit formingBenzodiazepine dervative. Has all the normal benzodiazepine-like quality (Anxiolytic/anticonvulsant/sedative/Skeletal muscle relaxant) It is also a prodrug for Desmethyldiazepam which is responsible for most if not all of the Effects of Prazepam.
Pregabalindepressant habit formingcommonPregabalin (Lyrica) is a GABA derivative that is used to treat neuropathic pain and seizures, as well as anxiety.
Propofolhabit formingdepressant A very short acting sedative that is usually given at the start of general anesthesia, and for maintenance of the prior. It should never be used outside of a medical setting. With that in mind, if you do plan to use this drug recreational, please have a very experienced friend with you that has the skills to insert a cannula, and monitor you very closely.
Propoxypheneopioiddepressant habit formingIs an analgesic in the opioid family. It is intended for mild pain and for its antitussive Effects. Has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias.
Propranololdepressant commonIs a nonselective beta blocker. It is used in medication for high blood pressure, anxiety, and tremors. Also fun fact, it was the first successful beta-blocker developed.
PSTopioiddepressant habit formingcommonPoppy Tea can be made from poppy pods, stalks and seeds, and contains various Opium alkaloids including primarily Morphine, as well as Codeine and others. There is great variation in Poppy Tea potency and therefor doses are indicated for opioid naive users.
Pyrazolambenzoresearch chemicalhabit formingdepressant RC benzodiazepine discovered by Hoffman-LaRoche in the 1970s. Came to the RC market in the early 2010s. At lower doses it is mainly an anxiolytic compound, yet at higher doses can be quite sedating, hypnotic, amnesic, and can cause loss of inhibitions. Structurally similar to Alprazolam, Bromazepam, and Triazolam. Is 12x as potent as Diazepam.
Quazepambenzodepressant habit formingBenzodiazepine derivate drug, noral is prescribed for short term treatment of insomnia, and sleep maintenance. its MOA is very similar to Ambien and Sonata and substitutes for those in animal studies.
Quetiapinedepressant An atypical antipsychotic medication under the brand name Seroquel. Also used to treat insomnia and mood swings. This drug is very sedating and can stop/slow down psychedelic drug trips. Infrequently abused.
Rilmazafonebenzohabit formingdepressant Unique to Japan, this drug, also known as Rhythmy, is a benzodiazepine pro-drug which while inactive itself, is metabolised into the active compound in-vivo. Soluble in water.
Ronlaxdepressant habit formingA benzodiazepine derivative that posses the standard benzodiazepine Effects. It has a very long half life (51-103 hours) it metabolizes into an active compound. (Descarboxyloflazepate) Is sold in Mexico.
Salviadissociativedeliriantdepressant commonA plant which, when smoked, causes short but very intense psychedelic experiences. It is considered physically safe, though users of high dosages often experience bizarre other-worldly scenarios which may be confusing or terrifying.
Secobarbitaldepressant habit formingbarbiturateA Barbiturate derivative that possesses all the classic Effects of todays Benzodiazepines, and the old Barbiturates. It's used in the treatment of Epilepsy, short term treatment for insomnia, and a preoperative medication for anaesthesia and anxiolysis for short surgical/diagnostic/therapeutic procedures.
Sonatadepressant habit formingcommonSedative-Hypnotic of the nonbenzodiazepine from the Pyrazolopyramide class. It is used mostly for short term insomnia.
Sufentanilopioiddepressant habit formingAn synthetic analgesic drug that is roughly between 5-10x the potency of it's parent drug, (Fentanyl); It's use is very contained to surgery and post-operative pain.
Tapentadolopioidhabit formingdepressant An opioid analgesic drug with potency somewhere between Tramadol and Morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.
Temazepambenzohabit formingdepressant Temazepam's brand name is Restoril. It is a hypnotic benzodiazepine with Effects similar to Clonazepam, frequently prescribed as a sleep aid. Some users report mild euphoria alongside the hypnotic Effects.
Tetrazepambenzohabit formingdepressant A benzodiazepine that has most of the properties of more common benzodiazepines. Yet was taken off the market in 2013. Has been noted to be more euphoric than most others.
Thiopentalbarbituratehabit formingdepressant Barbiturate that kicks in very quickly, that is used to Anesthesia, Medical induced comas among other things.
Tianeptineresearch chemicalhabit formingdepressant opioidA Tricyclic antidepressant, that has quite unique pharmacological properties than others in its class. Such as the possible indirect action on NMDA/AMPA and a full agonist at the μ-opioid receptor. While abuse of this substance is uncommon, it has been shown in a few countries.
Tilidineopioidhabit formingdepressant Synthetic opioid, used mainly for treatment of moderate to severe pain. In some countries it's mixed with Naloxone to lower the abuse liability. Though in some only Tilidine. Roughly 0.2 - 1 on the potency scale to Morphine. (So 20mg's of Morphine to 100mg's Tilidine)
Tramadolopioidhabit formingdepressant commonA synthetic opioid analgesic, Tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.
Trazodonedepressant A novel antidepressant of the SARI class, a serotonin antagonist and reuptake inhibitor. Often used to treat depression and anxiety. It has anxiolytic and hypnotic Effects.
Triazolambenzohabit formingdepressant An uncommon and very short acting benzodiazepine. Sedating and hypnotic, and may induce amnesia and lowered inhibitions at high doses.
Tuinalbarbituratedepressant habit formingBrand name of a combination drug of two barbiturate salts (Secobarbital/Amobarbital) in equal amounts. It was introduced in the late 1940's.
U-47700opioidresearch chemicalhabit formingdepressant A µ-opioid receptor agonist that is related to AH-7921. Having a very short duration.
U-51754tentativeopioiddissociativedepressant research chemicalA very potent opioid, that seems to have a fair bit of κ-opioid action. So Dyshopria, Auditory hallucinations can be an effect. Is an analogue of U-47700.
Valerylfentanylopioiddepressant research chemicaltentativehabit formingOpioid that is a higher homologue of Butyrfentanyl with greatly reduced potency.
W-15opioidresearch chemicalhabit formingtentativedepressant A potent opioid that is 5.4x more potent than Morphine. Has a distinct structure unrelated to nearly all other opioid compounds.
Zolazepambenzodepressant habit formingA substance that is structurally related to benzodiazepines. Is only used in Veterinary medicine. It is usually used in tandem with either the potent NMDA antagonist Tiletamine (at a 1:1 ratio) or with the α2 adrenergic receptor agonist Xylazine. Is roughly around four times the potency of Diazepam. Yet is water soluable.
Zolpidemdepressant habit formingcommonCommonly prescribed for insomnia, Ambien (Zolpidem) can cause realistic hallucinations similar to those of deliriants, and is very likely to cause amnesia at higher doses. Take care when using this drug, as it tends to lower inhibitions to a level which causes the user to do things they might not normally do when sober.
Zopiclonedepressant habit formingcommonA nonbenzodiazepine sedative sleep aid (Z-drug), which can have hallucinogenic Effects if taken while awake. Often causes users to have a metallic taste in the mouth for ~12h. Has been reported in some cases to cause certain users to black out, redose excessively and undertake dangerous activities such as driving.

Factsheets on 165 drugs