Dissociative

Dissociatives are mostly NMDA receptor antagonists, these substances are hallucinogenic but different than psychedelics. As per the name, these substances create a distance between the user and reality.

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NameCategoriesSummary
2-Chloroephenidinedissociativeresearch chemicaltentativeAn analogue of the dissociative drug Ephenidine, little is known about this obscure compound. Likely to exhibit dissociative effects, and be slightly less potent than Ephenidine.
2-FDCKtentativedissociativehabit formingDissociative anesthetic of the arylcyclohexylamine class. Seemingly on par with Ketamine in dosage. Longer onset than the prior.
3-HO-PCEdissociativeresearch chemicalhabit formingtentativeA rare and very potent PCP analogue, eight times more potent than PCP as NMDA receptor antagonist and also a μ-opioid receptor agonist. Similar in structure to methoxetamine.
3-HO-PCPdissociativeresearch chemicalhabit formingtentativeAn arylcyclohexamine dissociative analogue of PCP, this drug is relatively uncommon, and little information is available. It is reported to not only have dissociative activity but also be an opioid. Some trip reports suggest very negative side-effects including intense muscle tension.
3-MeO-PCEdissociativeresearch chemicalhabit formingtentative3-MeO-PCP with a change of a ring replacement. Slightly more potent than 3-MeO-PCP.
3-MeO-PCMOdissociativeresearch chemicaltentativeA less common dissociative anaesthetic compound related to PCP. An analogue of 3-MeO-PCP, but far less potent. Possibly an antitussive and antidepressant. Very little history of human use or pharmacological information.
3-MeO-PCPdissociativeresearch chemicalhabit formingcommonA potent dissociative often compared to MXE but with a longer duration, much less sedating effects and causing an overall different experience. Users have reported effects as being similar to PCP. Roughtly ten times more potent than 4-MeO-PCP.
3-MeO-PCPRdissociativetentativeresearch chemicalhabit formingThis is the N-Propyl homologue of 3-MeO-PCE. It is slightly less potent than PCP. Yet seems slightly less manic inducing.
3-MeO-PCPYdissociativehabit formingtentativeresearch chemical3-Methoxy analogue of Rolicyclidine (PCPy) less opioid effects than Phenylcyclidine (PCP) Yet still prominent.
4-MeO-PCPdissociativeresearch chemicalhabit formingAn arylcyclohexamine dissociative anaesthetic related to PCP. First discovered in the 1960s by Parke-Davis, it was introduced to the RC market in 2008. Reported to be less potent than PCP. It is not commonly seen, but has seen some increase in popularity with the inavailability of other dissociatives.
Deschloroketaminedissociativeresearch chemicalhabit formingtentativeA novel analogue of Ketamine which is much more potent and has a longer duration.
Diphenidinedissociativeresearch chemicalhabit formingtentativeA dissociative anaesthetic related to Ephenidine with similar qualities to PCP and Ketamine. Has seen some popularity as a recreational RC. Dosage curve has been reported as particularly steep, so care should be taken.
DXMdissociativehabit formingcommonCommonly found in certain over the counter cough medicines. Has dissociative effects similar to Ketamine or MXE, though also shares properties with opioids and Alcohol. Make sure DXM is the only active ingredient in the preparation.
Ephenidinedissociativeresearch chemicalhabit formingtentativeA dissociative drug which is less potent and less confusing than MXE but with otherwise similar properties. Reported as causing light stimulant effects at lower doses.
Ethketaminedissociativeresearch chemicalhabit formingEthketamine is a research chemical with properties similar to ketamine. While ketamine is a dissociative anesthetic producing hallucinogenic and sedative effects, recreational users have reported euphoria and dissociation when using NENK.
Fluorolintaneresearch chemicalhabit formingtentativedissociativeA dissociative anaesthetic also known as 2-FPPP, very little is known about this obscure and rare drug. Reported by some to be stimulating, having effects similar to other dissociative drugs such as PCP and Ketamine.
Ibogainepsychedelicopioiddissociativedepressant An alkaloid found in many African plants most famously Iboga, with psychedelic and hallucinogenic properties. May be unpleasant. Traditionally used in tribal environments for coming-of-age rituals, it has recently been used as an alternative treatment for drug addiction although this usage has not been backed by conclusive data in humans. Has killed in overdose.
Ketaminedissociativehabit formingcommonA short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with Alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."
MemantinedissociativetentativeAn NMDA-antagonist that if used recreationally can cause to a very prolonged "hole" lasting up to 16+ hours.
Methoxphenidinedissociativeresearch chemicaltentativehabit formingA dissociative from the diarylethylamine class, a more potent analogue of Diphenidine. Known to be unpredictable, and can cause blackouts.
Methoxyketaminedissociativeresearch chemicalhabit formingAn arylcyclohexylamine drug and analogue of Ketamine, though slightly less potent. Produces similar dissociative and anaesthetic effects. Very rare.
MK-801dissociativeresearch chemicaltentativehabit formingDissociative research chemical similar to PCP, and Ketamine. Dizocilpine, also known as MK-801, is a non-competitive antagonist of the NMDA receptor.
MXEdissociativeresearch chemicalhabit formingA popular dissociative drug which is an analogue of Ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.
MXMdissociativeresearch chemicalhabit formingAn arylcyclohexamine, dissociative and anaesthetic closely related to methoxetamine, Ketamine and PCP. It has seen some popularity among RC users, being advertised as an MXE replacement after its illegalisation in many parts of the world - however, users report a more stimulating experience closer to those caused by PCP and its analogues.
N2Odissociativehabit formingcommonN2O oxide, also known as laughing gas, often inhaled through balloons filled with canisters of the gas.. A short-acting dissociative inhalant with strong visual, mental and auditory effects. Extremely popular especially in combination with other drugs.
O-PCEdissociativeresearch chemicalhabit formingtentativeDissociative of the Arylcyclohexylamine class. Structurally related to Deschloroketamine.
PCEdissociativetentativehabit formingEticyclidine (PCE) is a Dissociative anesthetic that has hallucinogenic effects. Slightly more potent than Phencyclidine.
PCPdissociativehabit formingA strong dissociative drug. PCP works primarily as an NMDA receptor antagonist. Also referred to as "wet" or "angel dust". Best known for stories of the strange and sometimes violent behaviour of those under its influence, though it is likely these are only in overdose cases.
Rolicyclidinedissociativeresearch chemicalhabit formingtentativeRolicyclidine, also known as PCPy, is a dissociative with effects similar to PCP. While this dissociative anesthetic has hallucinogenic and sedative effects, it is said to be much less stimulating than PCP. In this sense it is more similar to opioids, or other central nervous system depressants.
Salviadissociativedeliriantdepressant commonA plant which, when smoked, causes short but very intense psychedelic experiences. It is considered physically safe, though users of high dosages often experience bizarre other-worldly scenarios which may be confusing or terrifying.
Tiletaminedissociativeresearch chemicaltentativehabit formingA relatively rare dissociative anesthetic, pharmacologically classified as an NMDA receptor antagonist. It is related to other anesthetics in this family such as Ketamine and phencyclidine. Has been used to cut Ketamine, in which case it may cause additional nausea. In Veterinary practice it is mixed with Zolazolam, a potent anaesthetic at a 1:1 ratio.
U-51754tentativeopioiddissociativedepressant research chemicalA very potent opioid, that seems to have a fair bit of κ-opioid action. So Dyshopria, Auditory hallucinations can be an effect. Is an analogue of U-47700.

Factsheets on 32 drugs