Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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NameCategoriesSummary
1,4-Butanedioldepressant habit forming1,4-BD is a clear liquid with intoxicating effects. It is a pro-drug for GHB, and has similar though reportedly inferior effects. It also carries the potential for more health risks than GHB, such as liver toxicity.
2-AIstimulantresearch chemicalhabit formingtentativeShort acting stimulant that is sometimes compared to the likes of Methamphetamine. It is a rigid analogue of Amphetamine, and also partially substitutes for the prior in rat discrimination studies.
2-DPMPstimulantresearch chemicalhabit formingA very potent stimulant that is a NDRI. Was developed by CIBA (Now called Novatris) in the 1950s, in which is was researched as a subject for narcolepsy and ADHD, yet was dropped quite quickly as Methylphenidate was produced a few years later, and seen as a superior substance for ADHD. Namely due to its shorter half life. 2-DPMP Half life is between 16-20 hours.
2-FAstimulantresearch chemicalhabit formingStimulant drug of the Amphetamine family. Reported as having effects similar to those of Dextroamphetamine, but with a milder euphoria and a comparatively smoother comedown. Has a shorter duration and less empathogenic effect-profile as compared with 4-FA. Thought not to have some of the neurotoxic metabolites Amphetamine can produce.
2-FDCKtentativedissociativehabit formingDissociative anesthetic of the arylcyclohexylamine class. Seemingly on par with Ketamine in dosage. Longer onset than the prior.
2-FMAstimulantresearch chemicalhabit formingA long-acting stimulant often compared to lisdexamphetamine. Thought not to have some of the neurotoxic metabolites Amphetamine can. Very functional, and for this reason it is frequently used for studying.
2-methyl-2-butanolhabit formingdepressant tentativeA tertiary Alcohol that has sedative, hypnotic, and anxiolytic effects. It is also roughly 20x more potent than Ethanol by weight.
2-MAstimulantresearch chemicalhabit formingtentativeAlso known as Ortetamine, this rarely seen Amphetamine is approximately 1/10th as potent as dextroamphetamine. Little information exists regarding its safety or effects.
2-MMCstimulanthabit formingtentativeresearch chemicalA cathinone, yet the effects are noted more of the likes of 2-FA or Amphetamine. Which apparently left people dissapointed.
2-MPPPresearch chemicalhabit formingstimulanttentativeA novel stimulant that is similar to methcathinone.
2-PAstimulantresearch chemicalhabit formingtentativeAmphetamine with the alpha-methyl replaced by ketone. Very few reports. Also no information on the safety of this compound. As always treat with caution.
2-PTAstimulantresearch chemicalhabit formingtentative4-Methylamphetamine with the alpha-methyl replaced by ketone. Very few reports. Also no information of the safety of this compound. As always treat with caution.
3,4-CTMPstimulantresearch chemicalhabit formingA strong stimulant, NDRI and analogue of Methylphenidate. Has increased in popularity in recent years. Said to be seven times more potent than Methylphenidate but with a slower onset, however discrimination studies have found it to be more addictive than Cocaine.
3-CMCstimulantresearch chemicalhabit formingtentativeA rarely seen halogenated cathinone drug. Likely to be a stimulant, possibly an entactogen. (Note: The Amphetamine analogue of this drug, 4-CA, is a highly dangerous neurotoxin, no data about the safety of this one, but should likely be avoided)
3-FAstimulantresearch chemicalhabit formingA stimulant that is close to equipotent with Methamphetamine and acts as a monoamine releasing agent , but has more selectivity for dopamine/noradrenaline over serotonin.
3-FEAstimulantresearch chemicalhabit formingA novel fluorinated Amphetamine compound that is structurally related to the X-FXA's.
3-FMAstimulantresearch chemicalhabit formingStimulant drug in the Amphetamine family
3-FMCstimulantresearch chemicalhabit formingA stimulant drug related to Mephedrone. A member of the cathinone class, it is also an Amphetamine. Effects similar to other drugs of its class, may possess high addiction potential. May be a monoamine releaser, reuptake inhibitor or both.
3-FPMstimulantresearch chemicalhabit formingA functional stimulant related to Phenmetrazine. Effects similar to Amphetamine, but longer and more focused. Observed as being relatively benign in low doses, but seems to cause worrying health effects for heavy users. Pain from insufflation is eye-wateringly intense, but short.
3-HO-PCEdissociativeresearch chemicalhabit formingtentativeA rare and very potent PCP analogue, eight times more potent than PCP as NMDA receptor antagonist and also a μ-opioid receptor agonist. Similar in structure to methoxetamine.
3-HO-PCPdissociativeresearch chemicalhabit formingtentativeAn arylcyclohexamine dissociative analogue of PCP, this drug is relatively uncommon, and little information is available. It is reported to not only have dissociative activity but also be an opioid. Some trip reports suggest very negative side-effects including intense muscle tension.
3-MECstimulantresearch chemicaltentativehabit formingAnother cathinone based stimulant, that is weaker than 4-MEC. Very few reports since it is quite unpopular.
3-MeO-PCEdissociativeresearch chemicalhabit formingtentative3-MeO-PCP with a change of a ring replacement. Slightly more potent than 3-MeO-PCP.
3-MeO-PCPdissociativeresearch chemicalhabit formingcommonA potent dissociative often compared to MXE but with a longer duration, much less sedating effects and causing an overall different experience. Users have reported effects as being similar to PCP. Roughtly ten times more potent than 4-MeO-PCP.
3-MeO-PCPRdissociativetentativeresearch chemicalhabit formingThis is the N-Propyl homologue of 3-MeO-PCE. It is slightly less potent than PCP. Yet seems slightly less manic inducing.
3-MeO-PCPYdissociativehabit formingtentativeresearch chemical3-Methoxy analogue of Rolicyclidine (PCPy) less opioid effects than Phenylcyclidine (PCP) Yet still prominent.
3-MeOMCstimulanthabit formingempathogenA cathinone that has a short history of human use.
3-MMCstimulanthabit formingempathogenA euphoric stimulant similar to Mephedrone but said to lack much of the "magic." Never gained the same popularity. Slightly less potent.
3-OH-PHENAZEPAMtentativeresearch chemicalbenzohabit formingdepressant The 3-OH analogue of Phenazepam, which cuts the half life down quite a bit. Psychoactive effects are mostly lead by its metabolites, rather than the drug itself.
4,4-DMARstimulantempathogenhabit formingtentativeVery closely related stimulant to Aminorex and Pemoline. Was sold as a designer drug for quite awhile under the brand name "Serotoni" has been linked to at least 31 deaths. It is a potent SNDRA.
4-Benzylpiperidinestimulantresearch chemicalhabit formingtentativeA dopamine releasing agent with weak serotonin releasing properties. Little evidence of human use. Potentially dangerous in overdose given MAOI + monoamine releasing properties.
4-CBCstimulantresearch chemicalempathogenhabit formingIs a potentially very neurotoxic Cathinone. Obviously no scientic reports have been noted on the neurotoxicity or cardiotoxicity, so please move on with extreme caution.
4-CMCstimulantresearch chemicalhabit forming(Note this work is going off just a few users inputs, so take all of this with a grain of salt) The cathinone analogue of 4-CMA which is highly neurotoxic. It is not known if the cathinone family holds the same neurotoxicity problem as with the parent compound.
4-EMCstimulantresearch chemicalhabit formingA stimulant that is a structural isomer of 4-MEC.
4-FAstimulantresearch chemicalhabit formingempathogencommonAn empathogen commonly used in place of MDMA. Has about the same duration of empathogenic effects but a longer stimulant "tail."
4-Fluoroethylphenidatestimulantresearch chemicalhabit formingtentativeA more potent and longer lasting analogue of Ethylphenidate.
4-Fluoromethylphenidatestimulantresearch chemicalhabit formingtentativeA relatively uncommon, more serotonergic RC derivative of Methylphenidate. A dopamine reuptake inhibitor possessing similar effects to associated stimulant compounds.
4-Fluoropentedronestimulantresearch chemicaltentativehabit formingAn obscure analogue of Pentedrone, little information exists about this cathinone. It is likely that it has the same general effects as Pentedrone, Mephedrone and other related stimulants.
4-FMAstimulantresearch chemicalhabit formingempathogenA stimulant with some empathogenic properties, and analogue of Methamphetamine with similar effects. Reported to be less effective than 2-FMA and related compounds. Little is known about the pharmacological effects of this compound.
4-FMCstimulantresearch chemicalhabit formingA cathinone stimulant also known as flephedrone, appeared in 2008 marketed as a Mephedrone replacement. With some mild empathogenic effects, it failed to achieve widespread popularity.
4-MECstimulantresearch chemicalhabit formingA substituted cathinone stimulant similar to related drugs like 4-MEC, little is known about the safety or subjective effects of this compound. It is believed to have similar effects to Mephedrone, but with a lower potency and a stronger stimulating character.
4-MeO-Butyrfentanyltentativeresearch chemicalopioidhabit formingRare and basically unknown opioid and fentanyl analogue (not to be confused with Butyrfentanyl). Virtually no reliable information exists, safe dosages are unknown. Exercise extreme caution. Overdose may result in respiratory depression. Do not mix with stimulants or depressants.
4-MeO-PCPdissociativeresearch chemicalhabit formingAn arylcyclohexamine dissociative anaesthetic related to PCP. First discovered in the 1960s by Parke-Davis, it was introduced to the RC market in 2008. Reported to be less potent than PCP. It is not commonly seen, but has seen some increase in popularity with the inavailability of other dissociatives.
4-METHYLAMINOREXstimulanthabit formingtentativeresearch chemicalA very potent stimulant that has quite a long duration of action at around 16 hours.
4-Methylmethylphenidatestimulantresearch chemicalhabit formingtentativeA stimulant drug related to Methylphenidate and also known as 4-Me-TMP, it has demonstrated lower dopamine reuptake inhibition properties and is potentially less potent. Has been subjectively described as very similar in feel to MPH.
4-MPDtentativestimulanthabit formingStimulant of the cathinone class. Higher homologue of Mephedrone, and the p-Methyl analogue of Pentedrone.
4F-PHPstimulantresearch chemicaltentativehabit forming4-Fluoro analogue of a-PHP, yet seems to have less mania attachted to it. Dose is near on par.
4F-PVPtentativestimulanthabit formingFluornated analogue of α-PVP. Seems to be slightly less weaker than it's parent compound.
5-APBpsychedelicstimulantresearch chemicalempathogenhabit formingA triple monoamine reuptake inhibitor. This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA.
5-APDBstimulantpsychedelicresearch chemicalempathogenhabit formingAn entactogenic Amphetamine stimulant with similar structure and effects to MDMA. An analogue of MDA, it is a highly selective serotonin releaser but inhibits reuptake of serotonin (weakly), dopamine and norepinephrine.
5-BPDIhabit formingresearch chemicalstimulanttentativeAn analogue of a-PHP, which has been described as having an extremely similar effect profile, with some users noting that it may be slightly lighter and with less of an urge to redose. However, little record of the safety of human use exists.
5-DBFPVtentativestimulanthabit formingresearch chemicalStimulant of the cathinone class. Analogue of MDPV where the methylenedioxyphenyl group was replaced with a dihydrobenzofuran.
5-EAPBstimulantpsychedelicresearch chemicalempathogenhabit formingA empathogen sold as a replacement to 5-MAPB after it was banned in the UK, but said to be less enjoyable and never gained much popularity.
5-IAIstimulantpsychedelicresearch chemicalhabit formingempathogenA monoamine triple releaser first synthesised by David Nichols, possesses similar properties to MDMA. Probably neurotoxic in humans, however the extent of this is unclear.
5-ITstimulantpsychedelicresearch chemicalhabit formingempathogenAn empathogenic stimulant with a very long duration, prone to cause overheating and potentially quite dangerous. Related to αMT, though described as being less psychedelic and with much stronger stimulating effects.
5-MAPBpsychedelicstimulantresearch chemicalempathogenhabit formingAn empathogen structurally similar to MDMA. Typically more visual than MDMA. Often reported to be much less stimulating and more relaxing than most other stimulating empathogens. Less psychedelic than 6-APB. Much longer lasting than MDMA.
5-PPDIstimulantresearch chemicalhabit formingtentativeAn obscure analogue of α-PBP, which is itself an analogue of α-PVP. This rare compound has little history of human usage. Some trip reports suggest it is inactive. If it is active it likely has a similar effect profile to other pyrovalerone stimulants.
5F-AKB48research chemicaltentativehabit formingA synthetic cannabanoid that is a Indazole. Produces subjective effects somehwat similar to that of Cannabis, yet with a very short duration. Analogue of STS-135, in which the core indole structure is subbed with an indazole base.
5F-PB-22tentativeresearch chemicalhabit formingSynthetic cannabinoid, agonist of the cannabinoid receptors which has a strong sedating aspect. Being a synthetic cannabinoid it has a very fast onset.
6-APBstimulantpsychedelicresearch chemicalempathogenhabit formingA stimulant, empathogen and analog of MDA. Typically more visual than MDMA or MDA, as well as having a much longer onset and duration. Users often report a slightly more psychedelic headspace as well. Commonly sold as an alternative to MDMA and MDA.
6-APDBstimulantpsychedelicresearch chemicalempathogenhabit formingA stimulant and entactogen related to MDMA and an analogue of MDA. Reported as being fairly psychedlic at higher doses. It is a triple monoamine reuptake inhibitor. Potent full agonist of serotonin 2B receptors.
6-EAPBstimulantpsychedelicresearch chemicalempathogenhabit formingA rare entactogen benzofuran structurally related to MDMA and 6-APB, though weaker in effects. the pharmacology of this compound is unclear. Likely to be a monoamine releaser, monoamine reuptake inhibitor or both.
6-MAPBstimulantpsychedelicresearch chemicalempathogenhabit formingEmpathogen drug that is structurally related to 6-APB and MDMA.
6-MDDMopioidhabit formingtentativedepressant A semisynthetic Hydromorphone derivative with little recorded history of human use. Potentially 80x the potency of Morphine. Structurally related to desomorphine.
A-PIHPstimulantempathogenhabit formingresearch chemicaltentativeQuite new Pyrrolidine based stimulant of the cathinone class. Not very many reports. Probably has a very fast tolerance raise, and lack of effects over time.
α-PVPstimulantresearch chemicalhabit formingA potent, short-lasting pyrovalerone-type stimulant which became popular despite often being said to not be particularly euporhic, perhaps due to its propensity to cause compulsive redosing. Effects should be similar to MDPV.
α-PVTstimulantresearch chemicalhabit formingtentativeA rare stimulant drug related to α-PVP, very uncommon. Probably less potent than α-PVP, however little data exists on this compound or its effects on humans.
AB-CHMINACAresearch chemicalhabit formingtentativeA synthetic cannabinoid related to AB-FUBINACA which has had some mild popularity. There have been reports of death in overdose, similar to AB-FUBINACA and it has a low threshold dose. Exercise caution.
AB-FUBINACAresearch chemicalhabit formingtentativecommonArguably the most common synthetic cannabinoid, AB-FUBINACA was originally developed by Pfizer as an analgesic, but has since abandoned for medical use. It has since found a following in the RC community, however it's extremely high potency and inclusion in synthetic blends makes it dangerous, and it has killed in overdose. Exercise caution.
Acetylfentanylopioidresearch chemicalhabit formingdepressant Acetyl-Fentanyl is an opioid analgesic substance that is an analogue of Fentanyl. It's potency is roughly ~6.67 times that of Morphine. Making it ~15 times less potent than its parent compound Fentanyl.
Acrylfentanylopioidresearch chemicalhabit formingtentativedepressant A rare opioid and Fentanyl analogue (not to be confused with acetyl-Fentanyl), this drug is a powerful and potent analgesic. Little reliable information exists, even for basic usage such as dosage. Exercise extreme caution. Overdose may result in respiratory depression. Do not mix with depressants or stimulants. Potentially neurotoxic and carcinogenic.
Adderallstimulanthabit formingcommonA mixture of 75% dextroamphetamine and 25% levoamphetamine. Commonly used to treat obesity, narcolepsy and ADHD. It is also used widely either as a recreational stimulant or study-aid, particularly in the USA where it is frequently prescribed.
Adinazolamdepressant habit formingtentativeBenzodiazepine derivative that has some antidepressant properties. Never FDA approved, yet however has been sold as a research chemical.
Adrafinilstimulantresearch chemicalhabit formingnootropicA prodrug to Modafinil, this compound is often used to increase wakefulness and alertness. Due to hepatic metabolism it has a slower onset than Modafinil and may cause liver damage in excess. Some users have reported acne as an adverse effect. Unregulated in the US.
Afloqualonedepressant habit formingtentativeA rare analogue of Methaqualone, a sedative, intoxicating drug. Similar effects to benzodiazepines, barbiturates and Alcohol. Never widely used due to photosensitivity and skin irritation issues, though it has seem some popularity in Japan.
AH-7921opioidresearch chemicalhabit formingdepressant Opioid analgesic that is selective for the μ-opioid receptor. It has around 80% the potency of Morphine when taken orally.
Alcoholdepressant habit formingcommonAlcohol is a CNS depressant that acts through the GABAreceptor, and is one of the most common strong psychoactives used by humans. It has a long history of use and its intoxicating effects are well-studied and documented. It remains legal in most parts of the world.
Allobarbitalbarbituratetentativedepressant habit formingIs a barbiturate that was first made in 1912. It was primilary used as an anticonvulsant. Yet it has pretty much been outclassed by a newer generation of safer ones. Still in use in Poland.
α-PHPstimulantresearch chemicalhabit formingtentativeA powerful stimulant cathinone, analogue of alpha-PVP and related to pyrovalerone. Said to have high addictive potential, compulsive redosing and relatively short duration. Often insufflated or vapourised.
Alprazolambenzohabit formingdepressant commonAn extremely common benzodiazepine better known as Xanax, frequently prescribed for the treatment of anxiety and panic disorders. Alprazolam is short-lasting and primarily anxiolytic, though also possesses hypnotic properties. At high doses amnesia and loss of inhibition are common. Do not mix with other depressants.
AM-2201research chemicaltentativehabit formingA synthetic cannabanoid that is very potent. Active doses start at around 250ug's. Please be cautious with this substance. It has also been noted that it can cause convulsions.
Amfonelic acidstimulantresearch chemicalhabit formingnootropicA dopaminergic stimulant discovered by Sterling-Winthrop accidentally while developing antibiotics. Discontinued due to undesirable stimulant effects, it has had some popularity as a recreational drug.
Aminorexstimulanthabit formingtentativeIs an anorectic stimulant drug that was taken of the market after it was found to cause pulmonary hypertension. Potency wise it has been found to be roughly 2.5 times more potent than dextroamphetamine.
Amobarbitaldepressant habit formingbarbiturateA sedative and hypnotic barbiturate first discovered in 1923. Formerly widely used recreationally and medically, barbiturates have declined in popularity with the appearance of benzodiazepines and other drugs with less serious consequences in overdose.
Amphetaminestimulanthabit formingcommonA very popular CNS stimulant available on prescription and black markets. Recreational in high doses, producing mild euphoria and an abundance of energy. Popular in eastern europe and the US.
Armodafinilstimulantnootropichabit formingThe more potent of the two Modafinil isomers, said to have a longer duration and lesser side effects. Sometimes prescribed for ADHD and daytime sleepiness.
Baclofendepressant habit formingAlso known as Lioresal, Baclofen is a GABAb receptor agonist and central nervous system depressant used to treat spasticity, and holds promise as a treatment for alcoholism. It exhibits mild intoxicating effects similar to Phenibut or Pregabalin.
Barbitalbarbituratehabit formingdepressant The first commercially available barbiturate. Was used commonly as a sleeping aid until the 1950s.
Bentazepambenzodepressant habit formingThienodiazepine that is an effective anxiolyric. Liver damage among other nasty things have been reported.
Bromadolopioiddepressant habit formingtentativeA very potent opioid that has an arylcyclohexylamine structure. Intial studies estimated that it was ~10,000x Morphine in animal studies. However that value has since decreased to ~504 times the potency of Morphine for the trans-isomer.
Bromazepambenzohabit formingdepressant A benzodiazepine drug with a medium-long duration, developed by Roche in the 1960s. Has primarily anxiolytic properties. May cause lowered inhibitions and amnesia in high doses.
Bromazolambenzoresearch chemicaltentativehabit formingA rather novel Benzodiazepine that is structurally quite close to Alprazolam.
Brotizolamdepressant benzohabit formingdepressant Benzodiazepine analogue which is sedating, hypnotic and anxiolytic. It is available as prescription medicine in much of Europe, and is an extremely potent drug active at only 80ug. May cause amnesia and lowered inhibitions in overdose. Danger of respiratory depression when combined with other depressants. Short half life.
Buphedronestimulantresearch chemicalhabit formingA cathinone stimulant first discovered in 1928, has gained some modest popularity as a Mephedrone replacement. Said to be to be around 2-3x more potent than methcathinone.
Buprenorphineopioidhabit formingdepressant A semi-synthetic opioid analgesic also known as subutex. Often administered as Butrans patches, or in combination with Naloxone as Suboxone, a Heroin replacement therapy drug. Will cause withdrawals if you have an opioid tolerance and DON't wait long enough (typically around 48 hours) before taking this.
Bupropionstimulanthabit formingA frequently prescribed atypical antidepressant. Occasionally prescribed as an aid to smoking cessation. May lower seizure threshold in predisposed individuals. Poorly understood mechanism of action, probably an NDRI. Avoid combination with other drugs.
Butylonepsychedelicstimulantresearch chemicalhabit formingempathogenEmpathogen and stimulant of the cathinone class.
Butyrfentanylopioidresearch chemicalhabit formingtentativedepressant Potent short-acting opioid and Fentanyl analogue. Often dispensed in a nasal spray. This is an highly potent drug - exercise extreme caution. May cause respiratory depression and death in overdose.
BZPstimulantresearch chemicalhabit formingA stimulant that was sold as "legal ecstasy" in the late 2000s, and was one of the first drugs widely marketed as a "research chemical." It has a much less favourable effect profile and has fallen out of popularity greatly since it was banned in many countries.
Caffeinestimulanthabit formingnootropiccommonCaffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.
Camazepambenzohabit formingtentativedepressant A benzodiazepine drug that is stronger in terms of anxiety relief than it is in terms of how hypnotic it is. It is a metabolite of Diazepam and has limited anticonvulsant properties.
Cannabisdepressant stimulantpsychedelichabit formingcommonA common and widely used psychoactive plant, which is beginning to enjoy legal status for medical and even recreational use in some parts of the world. Usually smoked or eaten, primary effects are relaxation and an affinity towards food - a state described as being 'stoned.'
Carisoprodoldepressant habit formingA skeletal muscle relaxant drug also known as Soma, Carisoprodol has limited recreational value, however its main metabolite meprobamate has some moderate tranquilising properties. Sometimes found in concoctions with Codeine or Caffeine.
Chloral betainedepressant habit formingSedative-hypnotic drug that was introduced into the United States in the 60's. Betaine complex with Chloral hydrate, thus makes it act as an extended version of Chloral hydrate then to Trichloroethanol, which is responsible for most of its effects.
Chloroformdepressant habit formingtentativeA naturally occurring organic compound once used as an anaesthetic. Has practically disappeared in this usage due to numerous harmful effects including danger of sudden death through cardiac arrhythmia. Has been implicated in numerous murders. Highly unsafe.
Cinolazepamdepressant habit formingA benzodiazepine derivative drug with anxiolytic effects but mainly hypnotic effects. It is extremely effective for sleep aid but has mild euphoria compared to other benzos
Clobazambenzohabit formingdepressant A long acting half life benzo that focues on Anxiolytic and/or Anticonvulsant.
Clomethiazoledepressant research chemicalhabit formingtentativeStructurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute Alcohol withdrawal.
Clonazepambenzohabit formingdepressant commonA medium-length common prescription benzodiazepine, often used to treat panic attacks because of its relatively fast sublingual onset. Primarily anxiolytic, but also possessing of other benzo traits.
Clonazolambenzoresearch chemicalhabit formingdepressant commonA long lasting benzodiazepine with heavily hypnotic effects. The safety profile is not well established, and there have been reports that people taking it three days in a row have had a seizure. Most comparable to Triazolam, but with a much longer half-life.
Cloniprazepambenzodepressant habit formingtentativeProdrug for Clonazepam.
Clonitazeneopioidhabit formingdepressant research chemicalAn opioid that is roughly three times as potent as Morphine. Is related to Etonitazene, which is about 1000-1500x the potency of Morphine.
Clorazepatedepressant benzohabit formingdepressant Is a prodrug for Desmethyldiazepam which is responsible for most of the therapeutic effects. Has a long half life, with the addition of Desmethyldiazepam as the main metabolite, which makes it much longer.
Clotiazepambenzohabit formingtentativedepressant Is a thienodiazepine substance. It differs from most other benzodiazepines in which the benzene ring has been replaced by a thiophene ring.
Cloxazolamdepressant habit formingBenzodiazepine derivate that is metabolised into Delorazepam. Which is where most of its effects come from.
Cocainestimulanthabit formingcommonA highly popular, short acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.
Codeineopioidhabit formingdepressant commonCodeine is a weaker opioid used to treat mild to moderate pain and to relieve cough. In many countries it is available over the counter in combination with paracetamol, which can easily be extracted to retrieve near-pure Codeine. For this reason, it is used widely as a recreational opioid. It is metabolised into Morphine in the body at a rate of 5% mg for mg.
Cyclo-Methiodroneempathogenstimulanthabit formingresearch chemicaltentativeEmpathogen with strong stimulant effects, very loosely related to benzylpiperidine.
Cyclobenzaprinedepressant habit formingcommonMuscle relaxant and CNS depressant used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Sometimes prescribed off-label for treatment of fibromyalgia or as a sleep aid. Has little recreational value alone, but may potentiate some opioids. May cause drowsiness, dry mouth and dizziness.
D2PMstimulanthabit formingtentativeAn NDRI, which is reported as being rather lackluster.
Delorazepambenzohabit formingdepressant Also known as chlordesmethyldiazepam, this uncommon benzodiazepine compound is primarily used for treatment of anxiety and Alcohol withdrawal, due to its long half-life (60-140 hours). It is also the active metabolite of Diclazepam and Cloxazolam.
Pethidineopioidhabit formingdepressant A phenylpiperidine opioid first synthesised by Otto Eisleb in 1939, better known by the names meperidine and pethidine. An analgesic, once widely prescribed it has since declined in usage due to the discovery of a toxic metabolite - norpethidine. Also reacts dangerously with many drugs.
Deschloroetizolambenzoresearch chemicalhabit formingtentativedepressant A Thienodiazepine which is close to its parent compound, Etizolam, whilst being significantly weaker and longer lasting.
Deschloroketaminedissociativeresearch chemicalhabit formingtentativeA novel analogue of Ketamine which is much more potent and has a longer duration.
Desmethylflunitrazepamdepressant benzohabit formingresearch chemicalBenzodiazepine that is a metabolite of Flunitrazepam, and has been sold as a research chemical.
Dexedrinestimulanthabit formingcommonA highly abusable stimulant. It is rarely prescribed in the US to treat ADHD, and is very similar in effects to Adderall, as its main ingredient is 75% of what Adderall is.
Dextropropoxypheneopioiddepressant habit formingAn opioid analgesic that is an optical isomer of levopropoxyphene. Used to treat mild pain and often used for its antitussive properties. It has been taken off the market in Europe and US due to concerns of health issues relating to the Kidney, Liver, Heart and Respiratory Disorders. Just a bit stronger than Tramadol.
Diazepambenzohabit formingdepressant commonA very common and widely prescribed benzodiazepine with hypnotic and sedative qualities. The metre by which other benzodiazepines are compared. May cause amnesia and lowered inhibitions in excess. Has a relatively long half-life in comparison with other benzodiazepines.
Diclazepambenzohabit formingdepressant A benzodiazepine drug and analogue of Diazepam first synthesised by Leo Sternbach at Hoffman-LaRoche in 1960, it has become prominent as an RC benzodiazepine on the grey market in recent years, particularly with the decline in Etizolam availability. A sedative and hypnotic it is of intermediate to long half life with similar effects to Diazepam, though 10x more potent.
Diclofensinestimulantresearch chemicaltentativehabit formingA triple monoamine reuptake inhibitor developed by Hoffman-LaRoche in the 1970s as an antidepressant but discontinued, probably due to high abuse potential. Has not become popular as a recreational drug at this time. Acts as an SNDRI, mostly inhibits dopamine and noradrenaline.
Diethyl etherdepressant habit formingtentativeAn industrial solvent which is sometimes used recreationally as a dissociative anaesthetic, with a short length of action. Effects are similar to Alcohol. Leaves one's breath tasting and smelling strongly of ether for much longer than the experience lasts.
Dihydrocodeineopioidhabit formingdepressant A weak semi-synthetic opioid analgesic and antitussive (anti-cough) drug. Often sold as a syrup in combination with Aspirin or paracetamol. Not to be confused with the slightly less potent Codeine.
Diphenidinedissociativeresearch chemicalhabit formingtentativeA dissociative anaesthetic related to Ephenidine with similar qualities to PCP and Ketamine. Has seen some popularity as a recreational RC. Dosage curve has been reported as particularly steep, so care should be taken.
Dipipanoneopioiddepressant habit formingdepressant A powerful opioid of equivalent strength to Morphine, rarely seen outside of medical environments. Often used to treat severe pain where Morphine is contraindicated. Usually found in combination with the antihistamine Cyclizine, which potentiates it.
DMAAstimulantresearch chemicalhabit formingnootropicAlso known as methylhexanamine, this sympathetomimetic drug was developed as a nasal decongestant by Eli Lilly in the 1940s. It has been used as a weight loss aid and missold as a dietary supplement and component of some energy drinks. Carries a risk of heart attack, stroke and other life-threatening cardiovascular issues.
DXMdissociativehabit formingcommonCommonly found in certain over the counter cough medicines. Has dissociative effects similar to Ketamine or MXE, though also shares properties with opioids and Alcohol. Make sure DXM is the only active ingredient in the preparation.
Ephedrinestimulanthabit formingEphedrine is a sympathomimetic amine commonly used as a stimulant, concentration aid, decongestant, appetite suppressant, and to treat hypotension associated with anaesthesia. A Methamphetamine analogue and commonly used in the production of Methamphetamine.
Ephenidinedissociativeresearch chemicalhabit formingtentativeA dissociative drug which is less potent and less confusing than MXE but with otherwise similar properties. Reported as causing light stimulant effects at lower doses.
Estazolambenzohabit formingdepressant A rarely prescribed medium-duration prescription benzodiazepine. Mainly used as a hypnotic, it can cause amnesia and lowered inhibitions in excess.
Eszopiclonedepressant habit formingThe d-isomer of Zopiclone, this drug is a potent hypnotic 'Z' drug often used to treat insomnia. High doses may cause amnesia, delirium and lowered inhibitions. Should not be combined with any depressants. Limited recreational value.
Ethaqualonedepressant benzoresearch chemicalhabit formingdepressant Analogue of Methaqualone that was mostly marketed in France. Slightly weaker and shorter acting than the prior.
Ethketaminedissociativeresearch chemicalhabit formingEthketamine is a research chemical with properties similar to ketamine. While ketamine is a dissociative anesthetic producing hallucinogenic and sedative effects, recreational users have reported euphoria and dissociation when using NENK.
Ethylcathinonestimulantpsychedelicresearch chemicalhabit formingEthylcathinone is a synthetic stimulant. It is similar to ecstasy in the sense that it provides euphoria, feelings of empathy and openness, and a desire to talk with others. It also carries over to some of the negative effects of ecstasy, such as insomnia, tightened jaw muscles, and grinding of the teeth.
Ethylmorphineopioidhabit formingdepressant A medium-strength opioid analgesic and analogue of Morphine. Considered less potent than Morphine but more potent than Codeine, and has been used in Germany for this reason. Said to have a 'ceiling' effect where no more euphoria occurs with increased dosage. Under investigation as a maintainance drug in opioid dependence therapy.
Ethylonestimulantpsychedelicresearch chemicalhabit formingempathogenA euphoric stimulant often sold in place of MDMA since Methylone was banned. Slightly less potent and empathogenic than Methylone, it is often described as more of a 'straight stimulant.'
Ethylphenidatestimulantresearch chemicalhabit formingcommonPotent psychostimulant, similar to Methylphenidate. Note: Ethylphenidate should NOT be insufflated as it is known to be highly caustic and will cause serious harm to your nasal septum, even with light usage.
Etizolambenzoresearch chemicalhabit formingdepressant A thienodiazepine anxiolytic. Similar in action to benzodiazepine drugs. Relieves anxiety, causes sedation and mild euphoria. High doses can lead to losing memory of what happened while on the drug. Users often compulsively re-dose frequently leading to accidental blackouts. Can be found in pressed pharmaceutical pills from various countries, clandestine pill presses, or as a powder
Fentanylopioidhabit formingdepressant Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than Morphine, and is commonly used as a patch. Sometimes used as an adulterant for Heroin, which has led to many overdose deaths.
Flualprazolambenzohabit formingtentativeFluornated Alprazolam that is very close if not equipotent to the parent compound.
Flubromazepambenzoresearch chemicalhabit formingdepressant A somewhat common benzodiazepine drug. Sedative, hypnotic and anxiolytic, this compound is an analogue of Phenazepam. First discovered in the 1960s it was never marketed as a licit drug, but has recently become available as an RC. Not to be confused with Flubromazolam.
Flubromazolambenzoresearch chemicalhabit formingdepressant A very potent benzodiazepine derivative that is related to Triazolam and Pyrazolam. Popular in the research chemical scene, it is a potent sedative, hypnotic and anxiolytic. Potential for amnesia and reduced inhibitions in higher dose. Not to be confused with Flubromazepam, which is much less potent.
Fluclotizolambenzotentativeresearch chemicalhabit formingA derivative of Etizolam. There are conflicting reports on its dosage, though claims have been made that it is approximately 3x the potency of Etizolam, with a shorter half-life.
Flunitrazepambenzohabit formingdepressant Known as Rohypnol or 'roofies,' this infamous drug has similar qualities to most other benzodiazepines; sedating with strong hypnotic effects. Despite being known as a 'date rape drug' has only been implicated in a small number of such crimes. Danger of respiratory depression in combination with other depressants. May cause amnesia and lowered inhibitions in overdose.
Flunitrazolambenzodepressant habit formingtentativeA very potent hypnotic Benzodiazepine. Triazolo version of Flunitrazepam.
Fluorolintaneresearch chemicalhabit formingtentativedissociativeA dissociative anaesthetic also known as 2-FPPP, very little is known about this obscure and rare drug. Reported by some to be stimulating, having effects similar to other dissociative drugs such as PCP and Ketamine.
Fluorophenibuttentativedepressant habit formingAn anxiolytic analogue of GABA and Phenibut, with similar activity to the latter. Expected to be 5-10 times as potent as Phenibut, some preliminary reports suggest tolerance builds more slowly.
Flurazepambenzohabit formingdepressant Benzodiazepine with an extremely long half life, between 40 and 250 hours. Mainly used for general anxiety disorder. Sedating, hypnotic, anxiolytic. Potential for amnesia and reduced inhibitions in overdose.
Flutazolambenzohabit formingdepressant A benzodiazepine derivative. It was invented in Japan, and has mainly stayed in that area. Similar potency to Diazepam, yet produces a more marked sedation and impaired coordination. Usually used as a treatment for Insomnia. A hypnotic and sedative which may cause amnesia and lowered inhibitions in high doses.
Flutoprazepambenzohabit formingdepressant A potent benzodiazepine that is roughly 4-5x the potency of Diazepam and has a longer duration, rarely seen outside of Japan. Sedative, hypnotic and anxiolytic. May cause amnesia and loss of inhibitions in excess. Do not mix with other depressants.
Dexmethylphenidatestimulanthabit formingcommonThe psychoactive isomer of Methylphenidate, mostly used to treat ADHD. Twice as potent as Methylphenidate, and is said to have cleaner psychostimulant effects with fewer side effects.
Furanylfentanylresearch chemicalhabit formingtentativeopioiddepressant An extremely potent opioid analgesic and analogue of fentanyl. Concrete information is difficult to obtain about even basic properties like active dose, though it is believed to be slightly less potent and shorter in duration than Butyrfentanyl. Exercise extreme caution. Will cause respiratory depression in overdose.
Gabapentindepressant habit formingdepressant An analogue of GABA also known as Neurontin, originally developed to treat epilepsy. Commonly prescribed for neuropathic pain, it also has pronounced anxiolytic effects leading to its use in treating anxiety disorders.
GBLdepressant habit formingcommonA pro-drug to GHB whose rapid absorption leads it to have a faster onset and shorter duration. Used in a similar manner to GHB, as a less-toxic alternative to Alcohol. Consume slowly instead of as a "shot" to hugely improve safety and reduce overdose risk.
GHBdepressant habit formingcommonA euphoric depressant which is prescribed as a sleep aid and sometimes to help with Alcohol detox. Also used as a recreational depressant, as a non-toxic alternative to Alcohol, or to enhance sex.
Glaucineopioidhabit formingdepressant tentativeAn alkaloid that is found in several different scpecies in the Papaveraceae family. It has antiinflammatory and antitussive effects. Can also be referred to as Yellow Horned Poppy.
Glutethimidedepressant habit formingIs a hypnotic sedative that was introduced in 1954, as a "safe" alternative to barbiturates to treat insomnia. Anecdotally long term use has had effects similar to withdrawal, while still on a stable dose of the drug.
Halazepambenzohabit formingdepressant A less common prescription benzodiazepine and derivative of Nordazepam. Also known as Paxipam, it is no longer prescribed in the USA. Sedating, hypnotic and anxiolytic. High doses may induce amnesia and lowered inhibitions.
HDEP-28stimulantresearch chemicaltentativehabit formingMost likely a TRI, such as HDMP-28, short history of human use.
HDMP-28stimulantresearch chemicaltentativehabit formingAlso commonly known as methylnapthidate. A functional stimulant similar to Methylphenidate but with a longer duration. Not especially recreational.
Heroinopioidhabit formingdepressant commonA powerful opioid drug derived from Morphine, with two to four times the potency. Also known as diacetylmorphine. Infamous for its high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 while trying to find a less addictive alternative to Morphine. One of the most popular drugs of all time.
Hexedronestimulantresearch chemicaltentativehabit formingA rare Mephedrone analogue also known as MACP, a cathinone stimulant with similar effects to Pentedrone.
Hexententativestimulanthabit formingresearch chemicalA cathinone based stimulant. Hexen (aka Ethyl-Hexedrone) acts as an NDRI to produce it's effects, and as with most cathinones has a fast onset and short duration. This drug has very little history of human consumption and next to no research/data, and therefor should be treated with caution as a research chemical.
Hexobarbitalbarbituratedepressant habit formingtentativeIs a barbiturate that was once used for inducing anesthesia for surgery. It has a very rapid onset, and a short duration of effects.
Homomazindolstimulanttentativeresearch chemicalhabit formingA potent analogue of mazindol, a rare, atypical stimulant drug and appetite suppressant occasionally prescribed in cases of severe obesity.
Hydrocodonedepressant opioidhabit formingdepressant commonA Codeine-derived opioid generally unheard of outside the United States. Generally mild in effects, used as an analgesic and cough-supressant. Sometimes used recreationally.
Hydromorphoneopioidhabit formingdepressant An opioid that is roughly 5x the potency of IV Morphine. Only comes in IR tablets in the US, and is given mostly as XR in other countries. It is frequently used in hospitals for short, but immediate pain relief during procedures requiring the patient to be awake. Also frequently used as a recreational opiate.
Indapyrophenidonestimulanttentativeresearch chemicalhabit formingIndane analogue of Pyrophenidone, a NDRI stimulant with a short duration.
Isomethadoneopioidhabit formingtentativedepressant Once a pharmaceutical drug also known as isoamidone, this opioid analgesic and Methadone analogue was withdrawn from the market and is seldom seen today. Rarely abused, though reports state it is around twice as potent as Methadone, and more euphoric.
Isophenmetrazinestimulantresearch chemicaltentativehabit formingRare and little known analogue of Phenmetrazine, which is slightly more potent than other analogues. Probably a stimulating, appetite supressing drug with high addiction potential. Potentially a dopamine and/or norepinephrine releasing agent.
Isopropylphenidateresearch chemicalhabit formingtentativestimulantIPPH (or incorrectly IPH) is a novel piperidine based Methylphenidate analogue and NDRI stimulant, but comes with much less physical side effects.
Kannahabit formingdepressant A South African plant containing numerous psychoactive alkaloids, including mesembrine and mesembrenone. The first written account of the substance was in 1662. The pharmacology of these compounds is poorly understood, but they are suspected to be serotonin uptake inhibitors and potentially monoamine releasers. Said to suppress appetite, produce mild euphoria and reduce anxiety.
Kavadepressant habit formingTropical evergreen shrub with large heart-shaped leaves and woody stems. Its thick roots are mashed or ground and made into a cold and bitter-tasting beverage used similarly to Alcohol. It has a long history of ritual and recreational use in Pacific Polynesia and is now a common herbal product, used widely by those in certain societies as part of a 'Kava Culture.'
Ketaminedissociativehabit formingcommonA short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with Alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."
Ketazolamdepressant habit formingBenzodiazepine derivative that has most of the common benzodiazepine effects. Has been seen to have similar effectiveness when compared to Diazepam, with milder side-effects. Is marketed in few countries.
Ketobemidoneopioidhabit formingdepressant An opioid analgesic drug that also acts as an NDMA antagonist. Found to be as potent as Morphine in physical side effects, and has high potential for addiction like all opioids do. Overdose may lead to respiratory depression/death. Do not mix with CNS depressants or stimulants. Caution should be used for asthmatic users.
Khathabit formingstimulantA shrub whose leaves contain Cathinone and Cathine, they are mostly chewed for the stimulant effect they provide. Very long history of human use.
Kratomopioidstimulanthabit formingdepressant commonA drug made out of the leaves of Mitragyna Speciosa, which is related to coffee. Stimulating at lower doses, with opioid effects at higher doses. Frequent heavy use can cause physical addiction and withdrawals.
Libriumbenzohabit formingdepressant Chlordiazepoxide, a medium-acting benzodiazepine drug prescribed mostly for sleep purposes. Sedative and hypnotic, it may cause lowered inhibitions and amnesia in high doses.
Loprazolamdepressant habit formingIs an Imidazolobenzidazepine derivative that has all the classic benzodiazepine effects. Is usually only prescribed for a short amount of time for insomnia.
Lorazepambenzohabit formingdepressant commonAn intermediate acting benzodiazepine commonly known as Ativan, commonly prescribed as an alternative to Xanax. Sedating, hypnotic and anxiolytic. Potential to induce amnesia and lowered inhibitions in overdose. Do not combine with other depressants.
Lormetazepambenzodepressant habit formingRelatively rare prescription benzodiazepine. Short acting with a short half life. Generally only seen in the Netherlands. Sedative, hypnotic and anxiolytic.
MBDBstimulantresearch chemicaltentativeempathogenhabit formingA rare entactogenic drug and analogue of MDMA possibly first synthesised by David Nichols. Potentially less potent than related drugs of its type. Sometimes referred to as a 'watered down MDMA.'
MBZPstimulantresearch chemicaltentativehabit formingA stimulant drug which is a derivative of BZP.
MDApsychedelicstimulantempathogenhabit formingcommonA stimulant and empathogen. Similar to MDMA but typically produces more visuals than MDMA. Known to be more neurotoxic than MDMA, and is a minor metabolite of MDMA. Duration and onset similar to MDMA. The common Marquis reagent test cannot differentiate MDA and MDMA.
MDAIpsychedelicstimulantresearch chemicalhabit formingempathogenA selective serotonin releasing agent which is rarely used without a stimulant to gain desirable effects. Not believed to be neurotoxic.
MDMAstimulantpsychedelicempathogenhabit formingcommonThe world's most popular empathogen with powerful pro-social effects. Has been strongly linked to cognitive decline in excess. Popular at parties, it is often sold in powder or in pills, and may be adulterated with other similar chemicals.
MDOHstimulantpsychedelicresearch chemicaltentativeempathogenhabit formingAn entactogen, stimulant and psychedelic first synthesised by Alexander Shulgin, MDOH is an analogue of MDA. Described as highly psychedelic, it is likely a serotonin releasing agent. It has not seen widespread use, perhaps due to a number of reported negative side effects such as urinary retention and a heavy comedown.
MDPAempathogenresearch chemicalhabit formingtentativeAn obscure substituted methylenedioxyphenethylamine with practically no history of human use. Its pharmacological profile is largely unknown, but potentially exhibits similar properties to other MDxx compounds. May be a monoamine releaser, reuptake inhibitor or both.
MDPVstimulantresearch chemicalhabit formingMDPV is a potent, and extremely compulsive synthetic euphoric stimulant, which shares some empathogenic effects with MDMA. Has a reputation for causing psychosis. MDPV has been found in products sold as "bath salts", "plant food/fertilizer", and in some "ecstasy."
Mebroqualonedepressant research chemicalhabit formingtentativeA short acting analogue of Methaqualone, that is much more potent.
Meclonazepambenzohabit formingdepressant tentativeA benzodiazepine related to Clonazepam discovered by Hoffman-LaRoche in the 1960s. Potentially useful in treating schistosomiasis. Has been sold on the grey market as a recreational drug but has not seen widespread popularity.
Medazepamdepressant benzohabit formingBenzodiazepine derivative that has all of the classic benzodiazepine effects. Is a long-acting benzodiazepine drug (Half life of 36-200 hours) Is rarely prescribed in most countries. Is also a prodrug for Diazepam. Think of it as Desoxy-Diazepam if you'd like to.
Mephedronestimulantresearch chemicalhabit formingempathogenA shortlived euphoric stimulant, developed as an analogue of MDMA, which was extremely popular in the research chemical scene before being banned. Commonly seen on street markets but rarer online. Very strong urge to redose compulsively.
4-MPMstimulantresearch chemicaltentativehabit formingempathogen4-Methylphenmetrazine is an empathogen of the phenylmorpholine class that seems to have a very rapid tolerance build up.
Methadoneopioidhabit formingdepressant commonA synthetic opioid drug used as an analgesic and is often used in detoxification off of other opioids. As it has a much longer half-life.
Methamnetaminepsychedelicstimulantresearch chemicaltentativeempathogenhabit formingA selective serotonin releaser, which also shows some light psychedelic activity. Almost always taken with a stimulant, to cause euphoric effects.
Methamphetaminestimulanthabit formingcommonA fairly common and very strong CNS stimulant. It is sometimes prescribed in the form of desoxyn for ADHD and severe obesity. In low doses, Methamphetamine can elevate mood, increase alertness, concentration, energy and reduces appetite. At higher doses, it can induce mania, psychosis and muscle degeneration among other issues. Tolerant users may report much higher doses than new users.
Methaqualonedepressant habit formingA pharmaceutical depressant and sedative phased out due to the better safety profile of benzodiazepines, part of the Qualone group of substances. Now very rare, except in South Africa.
Methedronestimulantresearch chemicalhabit formingBK-PMMA Closely related to PMMA and others. Stimulant.
Methoxphenidinedissociativeresearch chemicaltentativehabit formingA dissociative from the diarylethylamine class, a more potent analogue of Diphenidine. Known to be unpredictable, and can cause blackouts.
METHOXYACETYL-FENTANYLdepressant research chemicalhabit formingopioidA quite potent Fentanyl analogue.
Methoxyketaminedissociativeresearch chemicalhabit formingAn arylcyclohexylamine drug and analogue of Ketamine, though slightly less potent. Produces similar dissociative and anaesthetic effects. Very rare.
Methylmethaqualonedepressant research chemicalhabit formingA more potent analogue of Methaqualone with a short duration. Thought to be potentially neurotoxic. Has pro-convulsive effects.
Methylmorphenatestimulantresearch chemicalhabit formingtentativeStimulant of the phenylmorpholine class, an analogue of Methylphenidate where the piperidine ring has been replaced by a morpholine one, with ~1/10 potency.
Methylonestimulantpsychedelicresearch chemicalhabit formingempathogencommonβk-MDMA is a cathinone stimulant and empathogen, similar in structure to MDMA, though more stimulating and less empathogenic in comparison. Was very commonly mis-sold as MDMA on the street until it was banned in 2013. The Marquis reagent can differentiate βk-MDMA from MDMA. Less potent than MDMA with a slightly shorter duration.
Methylphenidatestimulanthabit formingcommonA psychostimulant commonly used in the treatment of ADHD, narcolepsy and obesity, particularly in the EU instead of Adderall. Methylphenidate is also a 5HT1A receptor agonist. Sometimes prescribed off-label to help the withdrawals from Cocaine and other stimulants.
Methyprylondepressant habit formingtentativeSedative of the pipeidinedone family. Was used for treating insomnia, yet is rarely used today due to substances with fewer side effects, such as benzodiazepines.
Metizolambenzoresearch chemicaldepressant habit formingtentativeAlso known as desmethyletizolam, a thienodiazepine similar in effects and structure to Etizolam, but around half as potent and with around a 60% longer half-life. A sedative, and hypnotic, it may cause amnesia and lowered inhibitions in excess.
Mexazolamdepressant habit formingBenzodiazepine derivative that has been trialed for anxiety and was found to be effective for anxiety at one week week follow-ups yet after three weeks it had lost its therapeutic anxiolytic properties and becoming no more effective than placebo.
Mexedroneempathogenstimulantresearch chemicalhabit formingtentativeMexedrone is a stimulant drug of the cathinone class. It alters the reuptake of serotonin, dopamine, and norepinephrine to cause euphoria, and is similar in effects to Mephedrone. It is considered a designer drug and is in a legally grey area globally.
Midazolambenzohabit formingdepressant A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines.
MK-801dissociativeresearch chemicaltentativehabit formingDissociative research chemical similar to PCP, and Ketamine. Dizocilpine, also known as MK-801, is a non-competitive antagonist of the NMDA receptor.
Modafinilstimulanthabit formingnootropiccommonA wakefulness promoting, long acting stimulant which is typically only used functionally, because there is no real euphoric component to its effects. Also prescribed for daytime sleeping disorders.
Morpheridineopioiddepressant habit formingtentativeIs a 4-Phenylpiperidine derivative that is related to Pehidine. It is roughly 4x as potent as the parent compound, does not cause convulsions such as Pethidine.
Morphineopioidhabit formingcommondepressant The prototypical opioid drug, a powerful analgesic with euphoric qualities, found in the seeds and wax of the plant papaver somniferum (Opium poppy). First isolated by Friedrich Sertürner in 1805, named for its sleep-inducing qualities. Do not combine with other depressants, may cause dangerous respiratory depression in overdose.
MPAstimulantresearch chemicalhabit formingAn analogue of Methamphetamine with effects close to amphetamine. Some users report negative side effects including stomach discomfort and sweating. Acts as a selective NDRI.
MT-45opioidresearch chemicalhabit formingdepressant A synthetic opioid drug that was rumoured to be roughly 80% the potency of Morphine orally. Was created by Dainippon Pharmaceutical in the 1970's. It has been used as a lead compound for the design of related substances. It has been associated with hearing loss and hair loss. Structurally unrelated to most other opioid drugs. Treat with caution, especially long term use.
MXEdissociativeresearch chemicalhabit formingA popular dissociative drug which is an analogue of Ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.
MXMdissociativeresearch chemicalhabit formingAn arylcyclohexamine, dissociative and anaesthetic closely related to methoxetamine, Ketamine and PCP. It has seen some popularity among RC users, being advertised as an MXE replacement after its illegalisation in many parts of the world - however, users report a more stimulating experience closer to those caused by PCP and its analogues.
Naphyronestimulantresearch chemicalhabit formingA drug derived from pyrovalerone which acts as a TRI, producing stimulating effects. Had been sold in a blend called "NRG-1" Little information exists about the safety profile of this drug.
NEBstimulantresearch chemicalhabit formingN-Ethylbuphedrone, an uncommon substituted cathinone. First appeared around 2011 but has not become popular. Effects should somewhat resemble other cathinones generally. Short-acting stimulating with more dopamine action than serotonin.
Nicomorphineopioiddepressant habit formingtentativeOpioid agonist that is 2-3x the potency of Morphine. Is used in few countries. Rapid onset of effects, due to the increased lipid solubility.
Nicotinehabit formingnootropiccommonA chemical found in tobacco, aubergines and tomatoes which is considered one of the most addictive drugs in existence. It is a mild stimulant, with stress relieving effects. It is widely used in the form of cigarettes, the use of which carries a high risk of causing cancer or heart issues over time. Increasingly, it is 'vaped' as a purportedly safer alternative to smoking.
Nifoxipambenzoresearch chemicalhabit formingtentativedepressant An uncommon and relatively new RC benzodiazepine, and metabolite of the hypnotic benzodiazepine Flunitrazepam. Little information about the pharmacological properties of this drug exists. Likely to be a strong sedative and hypnotic.
Nimetazepambenzohabit formingdepressant A pharmaceutical benzodiazepine with hypnotic and sedative effects. Rarely seen in the West but reportedly very frequently abused in Malaysia.
Nitemazepambenzodepressant habit formingtentativeA new RC benzodiazepine based off the chemical structure of Nimetazepam. It is relatively new and not many experience reports exist on it. It is expected to feel similar to Temazepam.
Nitracainestimulanttentativehabit formingAn analogue of dimethocaine with local anaesthetic and stimulant properties, marketed in the RC scene as a Cocaine replacement. Has not seen widespread popularity.
Nitrazepambenzohabit formingdepressant Hypnotic Benzodiazepine, that is used for short term relief of anxiety and insomnia. It has a pronouced affect on respritory action.
Nitrazolambenzohabit formingdepressant tentativeHypnotic benzodiazepine that is the triazolo analogue of Nitrazepam and about 4x more potent compared to the parent compound. Also the dechlorinated derivative of Clonazolam with roughly 1/10 potency.
N2Odissociativehabit formingcommonN2O oxide, also known as laughing gas, often inhaled through balloons filled with canisters of the gas.. A short-acting dissociative inhalant with strong visual, mental and auditory effects. Extremely popular especially in combination with other drugs.
Chloral hydratedepressant habit formingChloral Hydrate, a sedative drug discovered in 1832 with a history of recreational use going back to the 19th century. Sometimes prescribed for extreme insomnia. For such an old drug, relatively little is known about its long-term term effects on the body. Produces intoxication comparable to Alcohol or benzodiazepines.
Norflurazepambenzodepressant tentativehabit formingBenzodiazepine analogue that is an active metabolite to many other benzodiazepines, such as Flurazepam, Flutoprazepam, and Midazolam.
O-Desmethyltramadolopioidresearch chemicalhabit formingtentativedepressant A opioid analgesic which is the main active metabolite of Tramadol. Alone, it is a few times more potent than Tramadol and has additional affinity for δ and κ-opioid receptors. Has proven popular when sold, but these occasions have been rare due to patent rights.
O-PCEdissociativeresearch chemicalhabit formingtentativeDissociative of the Arylcyclohexylamine class. Structurally related to Deschloroketamine.
Opiumopioidhabit formingdepressant commonOpium is a naturally occurring analgesic harvested as a latex from ripe Papaver somniferum (Opium poppy) pods. The sap of the poppy plant primarily contains Codeine and Morphine with the amounts varying by plant, which can be made into a tea and consumed raw, or further processed.
Oxazepambenzodepressant habit formingA prescription benzodiazepine with intermediate duration and half life. A sedative and hypnotic which may cause lowered inhibitions and amnesia in higher doses.
Oxazolamdepressant habit formingA benzodiazepine derivative that is a prodrug for desmethyldiazepam.
Oxycodoneopioidhabit formingdepressant commonA semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.
Oxymorphoneopioidhabit formingdepressant A powerful semisynthetic opioid analgesic also known as opana. A derivative of Morphine it is approximately ten times as potent. Has a low oral bioavailability, and as such it is usually insufflated or taken rectally.
Pagoclonedepressant habit formingtentativeresearch chemicalAn anxiolytic drug related to Zopiclone with no sedative or hypnotic qualities. Has been investigated as a possible Alcohol replacement. Related in structure and effect to Zopiclone and Zolpidem.
Dextromoramideopioidhabit formingdepressant Dextromoramide, a rare and powerful opioid analgesic approximately three times as potent as Morphine with a shorter duration. Generally only seen in the Netherlands. Reported as having strange and rapid tolerance behaviour.
4-Fluorobutyrfentanylopioidresearch chemicalhabit formingdepressant Rare, little known and extremely potent RC analogue of Fentanyl. This powerful opioid is generally only dispensed as a nasal spray. Handle with extreme caution and never mix with other depressants.
Parafluorofentanylopioiddepressant habit formingtentativeRare, little known and extremely potent analogue of Fentanyl developed by Janssen Pharmaceutica in the 1960s. Use with extreme caution and never mix with other depressants.
PCEdissociativetentativehabit formingEticyclidine (PCE) is a Dissociative anesthetic that has hallucinogenic effects. Slightly more potent than Phencyclidine.
PCPdissociativehabit formingA strong dissociative drug. PCP works primarily as an NMDA receptor antagonist. Also referred to as "wet" or "angel dust". Best known for stories of the strange and sometimes violent behaviour of those under its influence, though it is likely these are only in overdose cases.
Pemolinestimulanthabit formingA stimulant of the 4-oxazolidinone class. Was used as a medication for ADHD and Narcolepsy, yet was pulled from most markets due to liver failures among children.
Pentazocinehabit formingdepressant opioidA synthetic opioid used as an analgesic. It is only used IM and IV in the medical field and has respiratory depressant effects. It is pregnancy category C and schedule IV in the US.
Pentedronestimulantresearch chemicalhabit formingA potent NDRI cathinone-type stimulant with more-ish effects but not thought to be especially enjoyable.
Pentobarbitaldepressant habit formingbarbiturateA CNS depressant drug that is of the barbituate class. Typically not used often as it is easier to OD on than benzodiazepines, the new alternative to barbituates. Used often for insomnia, to cause sedation.
Pentylonestimulantpsychedelicresearch chemicalhabit formingA stimulant, empathogen and substituted cathinone. It was first synthesised in the 1960s, and re-appeared on the research chemical scene in 2010. Still, very little is known about the pharmacology or effects of this compound.
Phenazepambenzoresearch chemicalhabit formingdepressant A very long acting, potent and subtle benzodiazepine. Infamous for the calamitous experiences it tends to produce in people dosing unknown amounts. Prescribed in certain countries for epilepsy and Alcohol withdrawal.
Phenetrazinestimulanthabit formingtentativeA rare phenethylamine stimulant related to 3-FPM. Virtually nothing is known about the pharmacology or effects of this compound but it is likely to have similar properties to other stimulants of its type. Not to be confused with Phenmetrazine.
Phenibutdepressant research chemicalhabit formingnootropicA derivative of GABA with the addition of a phenyl ring which allows it to cross the Blood Brain Barrier. Is mostly used as an anti-anxiety and anti-insomnia medication. Tolerance and physical dependency builds very quickly.
Phenmetrazinestimulanthabit formingStimulant drug that was previously used as an appetite suppresant, has been withdrawn from the market, due to concerns of abuse and addiction. Usually produces less nervousness, euphoria, and insomnia than drugs of the Amphetamine family. Also as a study concluded, it is slightly more effective than dextroamphetamine as a weight loss agent.
Phenobarbitaldepressant habit formingbarbiturateCNS depressant that is used mostly for insomnia (In older patients) and epliepsy (in younger patients) And it a very strong narcotic, that can be taken most ways. It's used less as "safer" alternatives have been made (Benzodiazepines).
Picamilonnootropicdepressant habit formingAn analogue of GABA that does pass the brain blood barrier, which is then hydrolyzed into GABA and Niacin. In which the GABA could produce an anxiolytic effect. The Niacin as a vasodilator. And is usually used as part of a nootropic stack.
Pinazepambenzodepressant habit formingBenzodiazepine that is solely an anxiolytic drug that lacks the hypnotic and motor impairment that most benzodiazepines do. The main metabolite of this is Nordazepam and to a lesser effect Oxazepam, which is where it gets most of its effects
Ethchlorvynoldepressant habit formingSedative Hypnotic medication made in the 50's. It was used for short term help for insomnia (No longer than two weeks)
Prazepambenzodepressant habit formingBenzodiazepine dervative. Has all the normal benzodiazepine-like quality (Anxiolytic/anticonvulsant/sedative/Skeletal muscle relaxant) It is also a prodrug for Desmethyldiazepam which is responsible for most if not all of the effects of Prazepam.
Pregabalindepressant habit formingcommonPregabalin (Lyrica) is a GABA derivative that is used to treat neuropathic pain and seizures, as well as anxiety.
Prolintanestimulantresearch chemicaltentativehabit formingA stimulant drug which is a dopamine reuptake inhibitor, related to MDPV and Pyrovalerone. It was first developed in the 1950s, and has seen some light usage in rave culture, though it remains relatively uncommon. Believed to have a relatively forgiving safety profile.
Propoxypheneopioiddepressant habit formingIs an analgesic in the opioid family. It is intended for mild pain and for its antitussive effects. Has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias.
Propylhexedrinestimulanthabit formingcommonA relatively common CNS stimulant sold over the counter in benzedrex inhalers.
Propylphenidatestimulantresearch chemicaltentativehabit formingPropylphenidate is a short acting stimulant.
PSTopioiddepressant habit formingcommonPoppy Tea can be made from poppy pods, stalks and seeds, and contains various Opium alkaloids including primarily Morphine, as well as Codeine and others. There is great variation in Poppy Tea potency and therefor doses are indicated for opioid naive users.
PV-8stimulantresearch chemicaltentativehabit formingStimulant of the pyrrolidinophenone class that is a higher homologue of α-PHP and generally less potent and less effective.
Pyrazolambenzoresearch chemicalhabit formingdepressant RC benzodiazepine discovered by Hoffman-LaRoche in the 1970s. Came to the RC market in the early 2010s. At lower doses it is mainly an anxiolytic compound, yet at higher doses can be quite sedating, hypnotic, amnesic, and can cause loss of inhibitions. Structurally similar to Alprazolam, Bromazepam, and Triazolam. Is 12x as potent as Diazepam.
Pyrophenidonestimulantresearch chemicalhabit formingtentativeAn NDRI pyrovalerone derivative reported to have very similar subjective effects. Virtually no information exists about this drug's effects in humans.
Quazepambenzodepressant habit formingBenzodiazepine derivate drug, noral is prescribed for short term treatment of insomnia, and sleep maintenance. its MOA is very similar to Ambien and Sonata and substitutes for those in animal studies.
Rilmazafonebenzohabit formingdepressant Unique to Japan, this drug, also known as Rhythmy, is a benzodiazepine pro-drug which while inactive itself, is metabolised into the active compound in-vivo. Soluble in water.
Rolicyclidinedissociativeresearch chemicalhabit formingtentativeRolicyclidine, also known as PCPy, is a dissociative with effects similar to PCP. While this dissociative anesthetic has hallucinogenic and sedative effects, it is said to be much less stimulating than PCP. In this sense it is more similar to opioids, or other central nervous system depressants.
Ronlaxdepressant habit formingA benzodiazepine derivative that posses the standard benzodiazepine effects. It has a very long half life (51-103 hours) it metabolizes into an active compound. (Descarboxyloflazepate) Is sold in Mexico.
RTI-111stimulantresearch chemicaltentativehabit formingStimulant of the Phenyltropane class that acts as a SNDRI. Presumably it will have a slightly slower onset and bit longer duration than its parent compound Cocaine. Yet being the Tropane analogue of 3,4-CTMP.
Secobarbitaldepressant habit formingbarbiturateA Barbiturate derivative that possesses all the classic effects of todays Benzodiazepines, and the old Barbiturates. It's used in the treatment of Epilepsy, short term treatment for insomnia, and a preoperative medication for anaesthesia and anxiolysis for short surgical/diagnostic/therapeutic procedures.
Sonatadepressant habit formingcommonSedative-Hypnotic of the nonbenzodiazepine from the Pyrazolopyramide class. It is used mostly for short term insomnia.
Sufentanilopioiddepressant habit formingAn synthetic analgesic drug that is roughly between 5-10x the potency of it's parent drug, (Fentanyl); It's use is very contained to surgery and post-operative pain.
Sulbutiaminetentativestimulanthabit formingsupplementA thiamine derivative nootropic and stimulant drug. Caution should be used as Sulbutiamine reduces dopamine output over time with consistant usage.
Tapentadolopioidhabit formingdepressant An opioid analgesic drug with potency somewhere between Tramadol and Morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.
Temazepambenzohabit formingdepressant Temazepam's brand name is Restoril. It is a hypnotic benzodiazepine with effects similar to Clonazepam, frequently prescribed as a sleep aid. Some users report mild euphoria alongside the hypnotic effects.
TETRAHYDROFURAN-FENTANYLopioidhabit formingdepressant research chemicalAn analogue of Fentanyl that is unknown in literature. Is most likely less potent than most other analogues. Yet very few reports are around. Be careful.
Tetrazepambenzohabit formingdepressant A benzodiazepine that has most of the properties of more common benzodiazepines. Yet was taken off the market in 2013. Has been noted to be more euphoric than most others.
TH-PVPtentativeresearch chemicalstimulanthabit formingA pyrovalerone stimulant related to α-PVP and Naphyrone. Very little information about effects or safety profile, virtually no evidence of human use.
Thiopentalbarbituratehabit formingdepressant Barbiturate that kicks in very quickly, that is used to Anesthesia, Medical induced comas among other things.
Thiopropaminestimulanthabit formingresearch chemicalA substance that is closely related to Methiopopramine (MPA). Is roughly about 1/3rd the potency of Amphetamine, differs from amphetmine from the phenyl ring is switched with a thiophene ring.
Tianeptineresearch chemicalhabit formingdepressant opioidA Tricyclic antidepressant, that has quite unique pharmacological properties than others in its class. Such as the possible indirect action on NMDA/AMPA and a full agonist at the μ-opioid receptor. While abuse of this substance is uncommon, it has been shown in a few countries.
Tiletaminedissociativeresearch chemicaltentativehabit formingA relatively rare dissociative anesthetic, pharmacologically classified as an NMDA receptor antagonist. It is related to other anesthetics in this family such as Ketamine and phencyclidine. Has been used to cut Ketamine, in which case it may cause additional nausea. In Veterinary practice it is mixed with Zolazolam, a potent anaesthetic at a 1:1 ratio.
Tilidineopioidhabit formingdepressant Synthetic opioid, used mainly for treatment of moderate to severe pain. In some countries it's mixed with Naloxone to lower the abuse liability. Though in some only Tilidine. Roughly 0.2 - 1 on the potency scale to Morphine. (So 20mg's of Morphine to 100mg's Tilidine)
Tolibutdepressant habit formingresearch chemicaltentativeAnalogue of GABA, and the 4-methyl analogue of Phenibut. Has similar effects, acts on GABA(B).
Tramadolopioidhabit formingdepressant commonA synthetic opioid analgesic, Tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.
Triazolambenzohabit formingdepressant An uncommon and very short acting benzodiazepine. Sedating and hypnotic, and may induce amnesia and lowered inhibitions at high doses.
Troparilstimulantresearch chemicaltentativehabit formingA stimulant and dopamine reuptake inhibitor developed in the 1970s, it is frequently used in scientific research but has seen little usage outside of the lab. Similar effects to Cocaine, though much longer and without any local anaesthetic action. Probably hard on the nose.
Tuinalbarbituratedepressant habit formingBrand name of a combination drug of two barbiturate salts (Secobarbital/Amobarbital) in equal amounts. It was introduced in the late 1940's.
U-47700opioidresearch chemicalhabit formingdepressant A µ-opioid receptor agonist that is related to AH-7921. Having a very short duration.
Valerylfentanylopioiddepressant research chemicaltentativehabit formingOpioid that is a higher homologue of Butyrfentanyl with greatly reduced potency.
Vyvansestimulanthabit formingcommonAlso known as lisdexamphetamine, this drug is a CNS stimulant often prescribed for ADHD, narcolepsy and obesity. It is also a pro-drug for dextroamphetamine, and functions as a method for providing extended-release stimulation. It is sometimes prescribed alongside an SSRI for depression.
W-15opioidresearch chemicalhabit formingtentativedepressant A potent opioid that is 5.4x more potent than Morphine. Has a distinct structure unrelated to nearly all other opioid compounds.
YERBA-MATEcommonstimulanthabit formingnootropicIs marketed for its ability to suppress appetite and burn fat. Yet only with high doses. It has a quite high ratio of Caffeine. It has anti-inflammatory properties.
Zolazepambenzodepressant habit formingA substance that is structurally related to benzodiazepines. Is only used in Veterinary medicine. It is usually used in tandem with either the potent NMDA antagonist Tiletamine (at a 1:1 ratio) or with the α2 adrenergic receptor agonist Xylazine. Is roughly around four times the potency of Diazepam. Yet is water soluable.
Zolpidemdepressant habit formingcommonCommonly prescribed for insomnia, Ambien (Zolpidem) can cause realistic hallucinations similar to those of deliriants, and is very likely to cause amnesia at higher doses. Take care when using this drug, as it tends to lower inhibitions to a level which causes the user to do things they might not normally do when sober.
Zopiclonedepressant habit formingcommonA nonbenzodiazepine sedative sleep aid (Z-drug), which can have hallucinogenic effects if taken while awake. Often causes users to have a metallic taste in the mouth for ~12h. Has been reported in some cases to cause certain users to black out, redose excessively and undertake dangerous activities such as driving.
α-PBPstimulantresearch chemicalhabit formingtentativeStimulant that is the homologue between α-PPP and α-PVP.

Factsheets on 311 drugs