Nootropics, otherwise known as "Smart Drugs" or "Cognitive Enhancers," are substances that can improve cognitive function, memory, creativity, motivation and can also aid in decreasing anxiety.

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Adrafinilstimulantresearch chemicalhabit formingnootropicA prodrug to Modafinil, this compound is often used to increase wakefulness and alertness. Due to hepatic metabolism it has a slower onset than Modafinil and may cause liver damage in excess. Some users have reported acne as an adverse effect. Unregulated in the US.
Amfonelic acidstimulantresearch chemicalhabit formingnootropicA dopaminergic stimulant discovered by Sterling-Winthrop accidentally while developing antibiotics. Discontinued due to undesirable stimulant effects, it has had some popularity as a recreational drug.
Aniracetamresearch chemicalnootropicAn anxiolytic nootropic which modulates the AMPA receptor. Significantly more potent than racetam. May have positive effects on memory and cognition. Little recreational value. Sold in Europe as a prescription drug, but not approved by the FDA in the US.
Armodafinilstimulantnootropichabit formingThe more potent of the two Modafinil isomers, said to have a longer duration and lesser side effects. Sometimes prescribed for ADHD and daytime sleepiness.
Bromantanedepressant stimulantresearch chemicalnootropicAn unusual stimulant and anxiolytic drug with dopamine and serotonin reuptake inhibition properties. Infamously used as a doping agent in the 1996 Olympics. There are some concerns it may exacerbate the underlying causes of Alzheimer's disease.
Caffeinestimulanthabit formingnootropiccommonCaffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.
Phenylpiracetamstimulantresearch chemicalnootropicA nootropic and Piracetam analogue also known as fonturacetam, this drug has been shown to have potential memory enhancing, anxiolytic, anti-amnesia and anti-depressive effects, however has little recreational value. Around 45x more potent than Piracetam.
CentrophenoxinenootropictentativestimulantCholinergic compound with a DMAE compotent. Is thought to help in reversing some signs of aging. Naturally found substance, most notably in fish.
Coluracetamresearch chemicalnootropicA nootropic drug of the racetam class, originally developed to treat Alzheimer's disease, it is currently being investigated as a treatment for major depressive disorder and generalised anxiety disorder. May be a modulator of the AMPA receptor. Limited recreational value.
CRL-40-940stimulanttentativenootropicresearch chemicalBisfluoro analogue Modafinil. Has been sold online as a research chemical. Was patented in 2013. Is slightly more potent than Armodafinil.
CRL-40-941stimulanttentativenootropicresearch chemicalA substance closely related to Adrafinil and Modafinil. It is the bis(p-fluoro) ring derivative of Adrafinil.
Dehydroxyfluorafinilstimulantnootropicresearch chemicaltentativeNootropic of the benzhydryl class. Closely related to Adrafinil and Modafinil. Was branded as "Modafiendz" through some research chemical vendors.
DMAAstimulantresearch chemicalhabit formingnootropicAlso known as methylhexanamine, this sympathetomimetic drug was developed as a nasal decongestant by Eli Lilly in the 1940s. It has been used as a weight loss aid and missold as a dietary supplement and component of some energy drinks. Carries a risk of heart attack, stroke and other life-threatening cardiovascular issues.
Fasoracetamresearch chemicalnootropictentativeA substance in the racetam family. Appears to be a GABA(B) agonist, and has shown to block memory disruptions caused by Baclofen, another GABA(B) Agonist. Similar to another compound in the racetam family Coluracetam, it enhances High affinity choline reuptake (HACU). Also research is conducted if it helps with ADHD and Congitive impairment.
HUPERZINE-AnootropictentativeA compound that is extracted from the herbs of Huperziceae family. Is known as an acetylcholinesterase inhibitor, which stops an enzyme from breaking down acetylcholine which results in increases in acetylcholine. Is currently in preliminary trials for Alzheimer's.
MelatoninnootropiccommonsupplementA naturally occurring hormone produced in the body, which promotes sleep at certain times in the day based on the circadian rhythm. It is also commonly available as a drug to treat insomnia and promote a proper sleep cycle. It can be used to promote sleepfulness at the tail-end of drug experiences, though it is not particularly hypnotic.
Modafinilstimulanthabit formingnootropiccommonA wakefulness promoting, long acting stimulant which is typically only used functionally, because there is no real euphoric component to its effects. Also prescribed for daytime sleeping disorders.
Nefiracetamnootropictentativeresearch chemicalNootropic compound of the racetam family. Seems to enhance both GABAergic and cholinergic signalling. Long term use appears to be neuroprotective. Fat soluble.
Nicotinestimulanthabit formingnootropiccommonA chemical found in tobacco, aubergines and tomatoes which is considered one of the most addictive drugs in existence. It is a mild stimulant, with stress relieving effects. It is widely used in the form of cigarettes, the use of which carries a high risk of causing cancer or heart issues over time. Increasingly, it is 'vaped' as a purportedly safer alternative to smoking.
Noopeptresearch chemicalnootropicA common nootropic often attributed with temporarily increasing intelligence, concentration, focus and memory recall. Daily use can lead to dependency with withdrawals which make the user feel 'stupid.' Often taken daily in a 'stack' with other nootropics.
PhenethylaminesupplementnootropicOrganic compound, which is a name of a class of chemicals that are quite well known for psychoactive and/or stimulant effects. Normally not used as a supplement as it is rapidly broken down into inactive compounds. Is found in many foods.
Phenibutdepressant research chemicalhabit formingnootropicA derivative of GABA with the addition of a phenyl ring which allows it to cross the Blood Brain Barrier. Is mostly used as an anti-anxiety and anti-insomnia medication. Tolerance and physical dependency builds very quickly.
Picamilonnootropicdepressant habit formingAn analogue of GABA that does pass the brain blood barrier, which is then hydrolyzed into GABA and Niacin. In which the GABA could produce an anxiolytic effect. The Niacin as a vasodilator. And is usually used as part of a nootropic stack.
PiracetamnootropicA racetam nootropic claimed by many to have cognitive benefits however this has never been strongly supported in healthy individuals. Prescribed in the UK as a treatment for myoclonus. Potentially an ampakine. One of the first popular 'nootropics.'
PPAPstimulantnootropicStimulant of the Amphetamine class, with an odd effect profile, and MOA.
PRL-8-53research chemicalnootropictentativeA nootropic research chemical first synthesized in the 70s. One study shows a drastic improvement in mid-term memory among users, but otherwise it is severely lacking in information surrounding it. It has no recreational potential.
TheacrinestimulantnootropicSmall alkaloid which can be seen as a structurally modified version of Caffeine, with similar stimulating effects. It also shares anti-inflammatory and analgesic effects with Caffeine.
YERBA-MATEcommonstimulanthabit formingnootropicIs marketed for its ability to suppress appetite and burn fat. Yet only with high doses. It has a quite high ratio of Caffeine. It has anti-inflammatory properties.

Factsheets on 28 drugs