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Ibogaine

Basic Information

Summary

An alkaloid found in many African plants most famously Iboga, with psychedelic and hallucinogenic properties. May be unpleasant. Traditionally used in tribal environments for coming-of-age rituals, it has recently been used as an alternative treatment for drug addiction although this usage has not been backed by conclusive data in humans. Has killed in overdose.

Psychedelic

Psychedelics are drugs which alter the perception, causing a number of mental effects which manifest in many forms including altered states of consciousness, visual or tactile effects.

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Opioid

Opioids are pain-killing depressants which may also cause euphoria.

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Dissociative

Dissociatives are mostly NMDA receptor antagonists, these substances are hallucinogenic but different than psychedelics. As per the name, these substances create a distance between the user and reality.

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Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Dose

Oral
Common16-22mg/kg
NOTEDoses

Duration

All ROAs
Onset45-180 minutes
Duration24-30 hours
After-effects24-72 hours

Aliases

iboga

Effects

Addiction help, Euphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil constriction, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.

See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • Ketamine
    • Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
  • MXE
    • This combination can potentiate the effects of the opioid
  • DXM
    • CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
  • Cocaine
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  • Alcohol
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
  • GHB/GBL
    • The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
  • Tramadol
    • Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
  • Benzodiazepines
    • Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

Caution

  • PCP
    • PCP can reduce opioid tolerance, increasing the risk of overdose
  • N2O
    • Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
  • Amphetamines
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  • MAOIs
    • Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.

Low risk & Increased Effects

Low risk & No Synergy

  • Mushrooms
  • LSD
  • DMT
  • Mescaline
  • DOx
    • No unexpected interactions.
  • NBOMes
  • 2C-x
  • 2C-T-x
    • No expected interactions, some opioids have serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
  • ╬▒MT
    • No unexpected interactions
  • 5-MeO-xxT
  • MDMA
  • Caffeine
  • SSRIs
    • There have been very infrequent reports of a risk of serotonin syndrome with this combination, though this should not be a practical concern.

References & Notes

General