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MDAI

Basic Information

Summary

A selective serotonin releasing agent which is rarely used without a stimulant to obtain desirable effects. Previously believed not to be neuruotoxic, however MDAI has been implicated in several lethal and non-lethal intoxications, and as such may pose more of a risk to health than previously believed.

Psychedelic

Psychedelics are drugs which alter the perception, causing a number of mental effects which manifest in many forms including altered states of consciousness, visual or tactile effects.

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Stimulant

Stimulants excite the nervous system and increase physiological function.

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Research Chemical

Research chemicals are drugs with relatively little history of human use, and thus particular care should be taken if choosing to ingest them.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Dose

Oral
Threshold20-40mg
Light40-100mg
Common100-150mg
Heavy150-300mg+

Duration

All ROAs
Onset30-60 minutes
Duration4-6 hours
After-effects1-8 hours
See TripSit Wiki for more information about drug interactions

Interactions

Dangerous

  • ╬▒MT
  • Tramadol
    • Tramadol and stimulants both increase the risk of seizures.
  • MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with amphetamine can lead to hypertensive crises.

Unsafe

  • DOx
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  • NBOMes
    • Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
  • 2C-T-x
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
  • 5-MeO-xxT
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
  • DXM
    • Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
  • PCP
    • This combination can easily lead to hypermanic states

Caution

  • Mushrooms
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • LSD
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • DMT
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • Mescaline
    • The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
  • 2C-x
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  • Cannabis
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • Ketamine
    • No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
  • MXE
    • Risk of tachycardia, hypertension, and manic states
  • Cocaine
    • This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
  • Caffeine
    • This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
  • Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
  • GHB/GBL
    • Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  • Opioids
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.

Low risk & Increased Effects

  • N2O
  • MDMA
    • Amphetamines increase the neurotoxic effects of MDMA

Low risk & Decreased Effects

  • Benzodiazepines
    • Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction

Low risk & No Synergy