The world's most popular empathogen with powerful pro-social effects. Has been strongly linked to cognitive decline in excess. Popular at parties, it is often sold in powder or in pills, and may be adulterated with other similar chemicals.
Stimulants excite the nervous system and increase physiological function.Read more on TripSit Wiki...
Psychedelics are drugs which alter the perception, causing a number of mental effects which manifest in many forms including altered states of consciousness, visual or tactile effects.Read more on TripSit Wiki...
These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.Read more on TripSit Wiki...
Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.
NOTE: Higher doses increase neurotoxic effects
Effects lovingly provided by PsychonautWiki
|Detection||1-3 days single use, 3-5 days heavy use|
|Marquis||Black (may have purple tint)|
|General-advice||Only roll every 2-3 months.|
- This combination can easily lead to hypermanic states
- The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
- Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care
- There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.
- Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
- Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA
- Both MDMA and alcohol cause dehydration. Approach this combination with caution, moderation and sufficient hydration. More than a small amount of alcohol will dull the euphoria of MDMA
- Large amounts of GHB/GBL may overwhelm the effects of MDMA on the comedown.
Low risk & Increased Effects
- Large amounts of cannabis may cause strong and somewhat unpredictable experiences in combination with MDMA. Cannabis should be saved for towards the end of the experience if possible.
- No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
- Amphetamines increase the neurotoxic effects of MDMA
Low risk & No Synergy
References & Notes
- Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity - http://www.ncbi.nlm.nih.gov/pubmed/10619665
- Involvement of free radicals in MDMA-induced neurotoxicity in mice. - http://www.ncbi.nlm.nih.gov/pubmed/11435997
- Methamphetamine and MDMA (ecstasy) neurotoxicity: 'of mice and men'. - http://www.ncbi.nlm.nih.gov/pubmed/15370888
- The neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine on serotonin, dopamine, and GABA-ergic terminals - http://www.ncbi.nlm.nih.gov/pubmed/15474609
- MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. - http://www.ncbi.nlm.nih.gov/pubmed/16220332
- Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB) - http://www.ncbi.nlm.nih.gov/pubmed/16234132
- 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings. - http://www.ncbi.nlm.nih.gov/pubmed/16541247
- The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans - http://www.ncbi.nlm.nih.gov/pubmed/17047932
- Neurogenic bladder and chronic urinary retention associated with MDMA abuse. - http://www.ncbi.nlm.nih.gov/pubmed/18570171
- THC Prevents MDMA Neurotoxicity in Mice - http://www.ncbi.nlm.nih.gov/pubmed/20174577
- Effects of a beta-blocker on the cardiovascular response to MDMA (Ecstasy). - http://www.ncbi.nlm.nih.gov/pubmed/20378736
- Neurotoxicity of ecstasy (MDMA): an overview - http://www.ncbi.nlm.nih.gov/pubmed/20420572
- MDMA: interactions with other psychoactive drugs - http://www.ncbi.nlm.nih.gov/pubmed/21756931
- MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans. - http://www.ncbi.nlm.nih.gov/pubmed/21924843
- MDMA (ecstasy) effects on actual driving performance before and after sleep deprivation, as function of dose and concentration in blood and oral... - http://www.ncbi.nlm.nih.gov/pubmed/21952668
- MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. - http://www.ncbi.nlm.nih.gov/pubmed/23179355
- MDMA Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner. - http://www.ncbi.nlm.nih.gov/pubmed/23457892
- Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical - http://www.ncbi.nlm.nih.gov/pubmed/23681166
- MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. - http://www.ncbi.nlm.nih.gov/pubmed/2452449
- MDMA, cortisol, and heightened stress in recreational ecstasy users. - http://www.ncbi.nlm.nih.gov/pubmed/25014666
- A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. - http://www.ncbi.nlm.nih.gov/pubmed/7516800
- Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. - http://www.ncbi.nlm.nih.gov/pubmed/7542394
- MDMA (ecstasy) inhibition of MAO type A and type B: comparisons with fenfluramine and fluoxetine (Prozac). - http://www.ncbi.nlm.nih.gov/pubmed/7945733
- Ecstasy use and serotonin syndrome: a neglected danger to adolescents and young adults prescribed selective serotonin reuptake inhibitors. - https://www.ncbi.nlm.nih.gov/pubmed/24006318
- 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. - http://www.ncbi.nlm.nih.gov/pubmed/11752122
- Putting an Ecstasy test kit to the test: harm reduction or harm induction? - http://www.ncbi.nlm.nih.gov/pubmed/14594341
- MDMA Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population. - http://www.ncbi.nlm.nih.gov/pubmed/16574714
- Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. - http://www.ncbi.nlm.nih.gov/pubmed/17881526
- Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. - http://www.ncbi.nlm.nih.gov/pubmed/19562632
- Neurotoxicity of ecstasy (MDMA): an overview. - http://www.ncbi.nlm.nih.gov/pubmed/20420572
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats - http://www.ncbi.nlm.nih.gov/pubmed/21615721
- Neurotoxicity of ecstasy and its metabolites in human dopaminergic differentiated SH-SY5Y cells. - http://www.ncbi.nlm.nih.gov/pubmed/23194825
- Neuroprotective properties of melissa officinalis L. Extract against ecstasy-induced neurotoxicity. - http://www.ncbi.nlm.nih.gov/pubmed/23671824
- Ecstasy use and serotonin syndrome: a neglected danger to adolescents and young adults prescribed selective serotonin reuptake inhibitors. - http://www.ncbi.nlm.nih.gov/pubmed/24006318
- MDMA, cortisol, and heightened stress in recreational ecstasy users - http://www.ncbi.nlm.nih.gov/pubmed/25014666
- History of MDMA - http://www.mdma.net/merck/history-ecstasy.html
- Study associating long-term serotonergic injury from use of MDMA - http://www.ncbi.nlm.nih.gov/pubmed/7643196
- Even after abstaining as long as 2.5 years, verbal memory deficits were still present in ex-mdma abuserd, indicating that the neurotoxicity may have some permanent damage features - http://m.jop.sagepub.com/content/20/2/211.short