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Midazolam

Basic Information

Summary

A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines.

Benzodiazepine

Benzodiazepines are generally hypnotic or anxiolytic depressant drugs.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Dose
Low5-10mg
Common10-15mg
Strong15-30mg+
Duration
Oral
Onset20-30 minutes
Duration4-8 hours
After-effects1-12 hours
Insufflated
Onset1-5 minutes
Duration4-8 hours
After-effects1-12 hours
IV
Onset0-1 minutes
Duration4-8 hours
After-effects1-12 hours
IM
Onset30-60 minutes
Duration4-8 hours
After-effects1-12 hours
Effects

    Effects lovingly provided by PsychonautWiki

    AvoidAll other CNS depressants.
    EffectsAnxiolytic, Sedative, Muscle Relaxant, Amnesia, Dystaxia, Hypnotic.
    BioavailabilityOral [variable - significant first-pass metabolism] | Insufflated 55% | Intramuscular 90%
    Bioavailability:Oral [Highly variable] | Insufflated 55% | Intramuscular 90%
    See TripSit Wiki for more information about drug interactions

    Interactions

    Dangerous

    Unsafe

    Caution

    Low risk & Increased Effects

    Low risk & Decreased Effects

    Low risk & No Synergy

    References & Notes

    Bioavailability