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Quetiapine

Basic Information

Summary

An atypical antipsychotic medication under the brand name Seroquel. Also used to treat insomnia and mood swings. This drug is very sedating and can stop/slow down psychedelic drug trips. Infrequently abused.

Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Dose

Light25mg-50mg
Common50mg-150mg
Strong150mg-300mg
Heavy300mg-800mg

Duration

All ROAs
OnsetOral minutes
Duration7-12 hours
After-effectsCan hours

Adverse-effects

dizziness, fatigue, extrapyramidal symptoms, increased diastolic blood pressure, increased triglycerides, increased total cholesterol, increased appetite, constipation, dry mouth, headache, and somnolence

Drug-contradictions

apomorphine, bromocriptine, cabergoline, carbamazepine, cimetidine, clarithromycin, dabrafenib, dopamine, erythromycin, idelalisib, itraconazole, ivacaftor, ketoconazole, levodopa, lisuride, mefloquine, methyldopa, nefazodone, ondansetron, panobinostat, pramipexole, rifabutin, rifampin, ropinirole, sodium oxybate, st. john's wort, vilanterol, and vemurafenib

Overdose-symptoms

sedation, hypotension, tachycardia, cardiac arrhythmia, coma, and death

Pharmacology

D1, D2, D3, and D4 receptor antagonist; 5-HT1A receptor partial agonist; 5-HT2A, 5-HT2C, and 5-HT7 receptor antagonist; α1-adrenergic and α2-adrenergic receptor antagonist; H1 receptor antagonist; mACh receptor antagonist

Aliases

seroquel

Effects

sedation, dizziness, fatigue, constipation, dry mouth, headache, appetite change, increased blood pressure

Chemistry

IUPAC: 2-(2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol | Formula: C21H25N3O2S | Molecular Mass: 383.5099 g/mol | Solubility in Water: 3.29 mg/mL (20 °C)

Legal

Australia: Prescription Only (S4) | United Kingdom: POM | United States: ?-only

See TripSit Wiki for more information about drug interactions

Interactions

No interaction information for Quetiapine