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Zopiclone

Basic Information

Summary

A nonbenzodiazepine sedative sleep aid (Z-drug), which can have hallucinogenic effects if taken while awake. Often causes users to have a metallic taste in the mouth for ~12h. Has been reported in some cases to cause certain users to black out, redose excessively and undertake dangerous activities such as driving.

Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

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Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

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Common

Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.

Dose

Oral
Threshold3.5mg
Light3.5-5mg
Common5-7.5mg
Strong7.5-15mg
Heavy15-22.5mg

Duration

All ROAs
Onset15 minutes
Duration3.5-9 hours
After-effects1-12 hours

Effects

Lethargy, tiredness, a dreamlike state while awake, can induce heavy sleep.

Aliases

imovane
zimovane

Contraindictions

Liver disease, myasthenia gravis, severe chronic bronchitis, emphysema, sleep apnea, thyroid gland abnormalities, trimipramine, caffeine, alcohol, erythromycin, itraconazole, rifampicin, phenytoin, carbamazepine, ketoconazole, sulfaphenazole, and nefazodone

Chemistry

IUPAC: (RS)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate | Formula: C17H17ClN6O3 | Molecular Mass: 388.808 g/mol

Pharmacology

GABA-A receptor positive allosteric modulator; Benzodiazepine receptor agonist

Pharmacokinetics

Protein Binding: 45 - 80% | Metabolism: various cytochrome P450 liver enzymes | Excretion: respiration (~50%) and urine (7 - 10 %)

Legal

Australia: Prescription Only (S4) | United Kingdom: Controlled Drug (POM) | United States: Schedule IV

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Interactions

No interaction information for Zopiclone

References & Notes

General