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mxe

Basic Information

Summary

A popular dissociative drug which is an analogue of ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.

Dissociative

Dissociatives are mostly NMDA receptor antagonists, these substances are hallucinogenic but different than psychedelics. As per the name, these substances create a distance between the user and reality.

Research Chemical

Research chemicals are drugs with relatively little history of human use, and thus particular care should be taken if choosing to ingest them.

Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

Read more on TripSit Wiki...

Dose

Insufflated
Threshold	5-10mg
Light	10-20mg
Common	20-35mg
Strong	35-60mg
Heavy	60mg+
M-Hole	70mg+

Oral
Threshold	10-15mg
Light	15-25mg
Common	25-35
Strong	40-65mg
M-Hole	75mg+

Sublingual
Threshold	5-10mg
Low	10-20mg
Common	40-60mg
Strong	60-75mg
M-Hole	75-100mg

NOTE: Bodyweight plays a slight factor in MXE dosing, these are values for a 175lb (80kg) male

Duration

Insufflated
Onset	5-20 minutes
Duration	3-6 hours
After-effects	2-48 hours

Oral
Onset	30-60 minutes
Duration	3-6 hours
After-effects	2-48 hours

Sublingual
Onset	15-45 minutes
Duration	3-6 hours
After-effects	2-48 hours

Aliases

methoxetamine
3-meo-2'oxo-pce

Avoid

Alcohol, Benzodiazepines, Opioids, Other CNS depressants, including substances that have an effect on Serotonin (For example, yet not limited to MDMA, Amphetamine, and other stimulants)

Legality

Methoxetamine is illegal in the US states Arizona, Florida, Indiana, Louisiana, Minnesota, North Dakota, Ohio and Virginia. It is also banned in Brazil, France, Germany, Japan, Russia and the UK.

See TripSit Wiki for more information about drug interactions

Interactions

No interaction information for MXE

References & Notes

General

Methoxetamine associated reversible cerebellar toxicity: three cases with analytical confirmation. - http://www.ncbi.nlm.nih.gov/pubmed/22578175
Methoxetamine: from drug of abuse to rapid-acting antidepressant. - http://www.ncbi.nlm.nih.gov/pubmed/22819129
From Special K to Special M: the evolution of the recreational use of ketamine and methoxetamine. - http://www.ncbi.nlm.nih.gov/pubmed/23421859
Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn - http://www.ncbi.nlm.nih.gov/pubmed/23774830
Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice. - http://www.ncbi.nlm.nih.gov/pubmed/24580056
Analytical findings of an acute intoxication after inhalation of methoxetamine. - http://www.ncbi.nlm.nih.gov/pubmed/24904014
Acute methoxetamine and amphetamine poisoning with fatal outcome: a case report - http://www.ncbi.nlm.nih.gov/pubmed/25060403
From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine. - http://www.ncbi.nlm.nih.gov/pubmed/23421859
Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn. - http://www.ncbi.nlm.nih.gov/pubmed/23774830
Acute methoxetamine and amphetamine poisoning with fatal outcome: a case report. - http://www.ncbi.nlm.nih.gov/pubmed/25060403~adddrugsource cannabis general Cannabis use in relation to obesity and insulin resistance in the Inuit population. - https://www.ncbi.nlm.nih.gov/pubmed/25557382
3 case reports of toxicity due to recreational use of MXE - http://link.springer.com/article/10.1007/s00228-011-1199-9