TripSit Factsheets - Pentazocine

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pentazocine

Basic Information

Summary

A synthetic opioid used as an analgesic. It is only used IM and IV in the medical field and has respiratory depressant effects. It is pregnancy category C and schedule IV in the US.

Habit-forming

These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.

Depressant

Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.

Opioid

Opioids are pain-killing depressants which may also cause euphoria.

IM
Light	10-20mg
Common	20mg-30mg
Strong	30-60mg

IV
Light	5-10mg
Common	10-20mg
Strong	30mg

Interactions

Dangerous

Ketamine
- Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
MXE
- This combination can potentiate the effects of the opioid
DXM
- CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
Cocaine
- Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Alcohol
- Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
GHB/GBL
- The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
Tramadol
- Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
Benzodiazepines
- Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

Caution

PCP
- PCP can reduce opioid tolerance, increasing the risk of overdose
N2O
- Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Amphetamines
- Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
MAOIs
- Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.

Low Risk & Increased Effects

Cannabis

Low Risk & No Increased Effects

Mushrooms
LSD
DMT
Mescaline
DOx
- No unexpected interactions.
NBOMes
2C-x
2C-T-x
- No expected interactions, some opioids have serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
αMT
- No unexpected interactions
5-MeO-xxT
MDMA
Caffeine
SSRIs
- There have been very infrequent reports of a risk of serotonin syndrome with this combination, though this should not be a practical concern.

IM
Onset	15-20 minutes
Duration	2-3 hours
After-effects	1-12 hours

IV
Onset	2-3 minutes
Duration	2-3 hours
After-effects	1-12 hours

Pentazocine